Initial in vitro screening approach to investigate the potential health and environmental hazards of Enviroxtrade mark - a nanoparticulate cerium oxide diesel fuel additive.
Initial in vitro screening approach to investigate the potential health and environmental hazards of Enviroxtrade mark - a nanoparticulate cerium oxide diesel fuel additive.
复制标题
DOI：
10.1186/1743-8977-4-12
复制
发表时间：
2007-12-05
影响因子：
10
通讯作者：
Handley J
中科院分区：
文献类型：
--
作者：
Park B;Martin P;Harris C;Guest R;Whittingham A;Jenkinson P;Handley J
纳米技术是21世纪的新工业革命，因为各种工艺导致医药、制造、能源生产、土地修复、信息技术和许多其他日常产品和应用的根本改善。然而，随着这场革命的到来，人们无疑对纳米级材料和工艺的独特性质引发了对健康、安全和环境的担忧。筛选策略中使用的体外试验都是经过验证的、国际公认的方案，并提供了一种有用的指示，表明一种化学物质由于对各种毒理学终点的影响而产生的潜在毒性，例如局部接触(皮肤)刺激、一般细胞毒性和诱变性。本文所述的初步体外筛查策略旨在调查在接触用作柴油催化剂的纳米颗粒氧化铈的特定应用后可能出现的潜在健康影响，这反映了一种预防方法，结果将为判断如何最好地进行以确保安全使用提供参考。
Nanotechnology is the new industrial revolution of the 21st Century as the various processes lead to radical improvements in medicine, manufacturing, energy production, land remediation, information technology and many other everyday products and applications. With this revolution however, there are undoubted concerns for health, safety and the environment which arise from the unique nature of materials and processes at the nanometre scale. The in vitro assays used in the screening strategy are all validated, internationally accepted protocols and provide a useful indication of potential toxicity of a chemical as a result of effects on various toxicological endpoints such as local site of contact (dermal) irritation, general cytotoxicity and mutagenicity. The initial in vitro screening strategy described in this paper to investigate the potential health implications, if any, which may arise following exposure to one specific application of nanoparticulate cerium oxide used as a diesel fuel borne catalyst, reflects a precautionary approach and the results will inform judgement on how best to proceed to ensure safe use.