Perspectives on the RNA polymerase II core promoter
Perspectives on the RNA polymerase II core promoter
复制标题
DOI：
10.1042/bst0341047
复制
发表时间：
2006-12-01
影响因子：
3.9
通讯作者：
Kadonaga, J. T.
中科院分区：
文献类型：
--
作者：
Juven-Gershon, T.;Hsu, J. -Y.;Kadonaga, J. T.
RNA聚合酶II核心启动子是转录过程中一个关键但经常被忽视的组成部分。核心启动子被定义为DNA片段，其包含RNA起始位点，并且通常约为100 bp。长度为40-50 nt，指导基因转录的起始。在过去，一般认为核心启动子在功能上是通用的，并且转录起始通过共同的共享机制发生。然而，最近的研究表明，核心启动子的结构和功能有相当大的多样性。存在许多有助于核心启动子活性的DNA元件，并且给定核心启动子的特定性质由这些核心启动子基序的存在或不存在决定。已知的核心启动子元件包括TATA盒、Inr（起始子）、BREu {TATA盒上游的BRE [TFIIB（RNA聚合酶IIB的转录因子）识别元件]}和BREd（TATA盒下游的BRE）、MTE（基序10元件）、DCE（下游核心元件）和DPE（下游核心启动子元件）。在这篇文章中，我们将提供一些关于RNA聚合酶II核心启动子当前和未来问题的观点。
The RNA polymerase II core promoter is a critical yet often overlooked component in the transcription process. The core promoter is defined as the stretch of DNA, which encompasses the RNA start site and is typically approx. 40-50 nt in length, that directs the initiation of gene transcription. In the past, it has been generally presumed that core promoters are general in function and that transcription initiation occurs via a common shared mechanism. Recent studies have revealed, however, that there is considerable diversity in core promoter structure and function. There are a number of DNA elements that contribute to core promoter activity, and the specific properties of a given core promoter are dictated by the presence or absence of these core promoter motifs. The known core promoter elements include the TATA box, Inr (initiator), BREu {BRE [TFIIB (transcription factor for RNA polymerase IIB) recognition element] upstream of the TATA box} and BREd (BRE downstream of the TATA box), MTE (motif ten element), DCE (downstream core element) and DPE (downstream core promoter element). in this paper, we will provide some perspectives on current and future issues that pertain to the RNA polymerase II core promoter.