Facile synthesis of monofunctional pentamethine carbocyanine fluorophores
Facile synthesis of monofunctional pentamethine carbocyanine fluorophores
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DOI：
10.1016/j.dyepig.2010.12.008
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发表时间：
2011-08-01
影响因子：
4.5
通讯作者：
Hilderbrand, Scott A.
中科院分区：
文献类型：
--
作者：
Shao, Fangwei;Yuan, Hushan;Hilderbrand, Scott A.
报道了一种高产率合成具有远红外/近红外（NIR）发射波长在650 ~ 700 nm的对称共轭五甲川碳菁染料的方法。所述染料通过吲哚鎓或苯并[e]吲哚鎓内盐与烷基羧酸衍生的丙二醛二苯胺的缩合或可替代地在一锅反应中而不分离丙二醛中间体来制备。荧光团是水溶性的，具有明亮的荧光发射，易于以良好的产率制备，并且是用于各种生物化学和体内成像应用的有希望的候选物。(C)2011爱思唯尔有限公司保留所有权利。
A high-yield route to symmetric, conjugatable pentamethine carbocyanine dyes with far-red/near infrared (NIR) emission between 650 and 700 nm is reported. The dyes are prepared via condensation of indolium or benz[e]indolium inner salts with an alkyl carboxylic acid derivatized malonaldehyde dianil or alternatively in a one-pot reaction without isolation of the malonaldehyde intermediate. The fluorophores are water-soluble, have bright fluorescence emission, are easily prepared in good yield, and are promising candidates for use in a variety of biochemical and in vivo imaging applications. (C) 2011 Elsevier Ltd. All rights reserved.