Glycemia, Diabetes Status, and Cognition in Hispanic Adults Aged 55-64 Years.
Glycemia, Diabetes Status, and Cognition in Hispanic Adults Aged 55-64 Years.
复制标题
DOI：
10.1097/psy.0000000000000208
复制
发表时间：
2015-07
影响因子：
3.3
通讯作者：
Teresi J
中科院分区：
文献类型：
--
作者：
Luchsinger JA;Cabral R;Eimicke JP;Manly JJ;Teresi J
研究曼哈顿北部600名年龄在55至64岁的西班牙裔人群中血糖和糖尿病状况与认知的关联。
通过病史或糖化血红蛋白（HbA1c）确定糖尿病。通过HbA1c确定正常葡萄糖耐量（NGT）和糖尿病前期。使用选择性提醒测试（SRT）评估记忆力。使用颜色连线测试1和2以及语言流畅性测试评估执行能力。使用线性回归分析血糖和糖尿病状况与认知表现的横断面关联。
参与者平均年龄为59.2±2.9岁，76.7%为女性，超过65%患有糖尿病前期或糖尿病。在对人口统计学特征、教育程度和血管危险因素进行调整后，HbA1C（β = -0.97；p <0.001）和糖尿病（β = -2.06；p = 0.001）与SRT总回忆量降低有关。在充分调整后，糖尿病前期与颜色连线测试2中较差的表现相关（β = -6.45，p = 0.022）。
较高的血糖水平和糖尿病与中年后期较差的记忆力和执行能力有关，而糖尿病前期仅与较差的执行能力有关。需要进行纵向随访以了解这些缺陷的顺序和进展。
To examine the association of glycemia and diabetes status with cognition among 600 Hispanics aged 55 to 64 years from Northern Manhattan. Diabetes was ascertained by history or Hemoglobin A1c (HbA1c). Normal glucose tolerance (NGT) and pre-diabetes were ascertained with HbA1c. Memory was assessed with the Selective Reminding Test (SRT). Executive abilities were assessed using the Color trails 1 and 2, and verbal fluency test. The cross-sectional association of glycemia and diabetes status with cognitive performance was examined using linear regression. Participants were a mean age of 59.2 ± 2.9 years old, 76.7% were women, and more than 65% had pre-diabetes or diabetes. HbA1C (β = − 0.97; p <0.001) and diabetes (β = − 2.06; p = 0.001) were related with lower SRT total recall after adjustment for demographics, education, and vascular risk factors. Pre-diabetes was associated with worse performance in color trails 2 (β = − 6.45 p = 0.022) after full adjustment. Higher glycemia and diabetes are related to worse memory and executive abilities in late middle age, while pre-diabetes is related only to worse executive abilities. Longitudinal follow-up is needed to understand the order and progression of these deficits.