Current understanding of GUN1: a key mediator involved in biogenic retrograde signaling
Current understanding of GUN1: a key mediator involved in biogenic retrograde signaling
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发表时间：
2019
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通讯作者：
Chanhong Kim.
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作者：
Paolo Pesaresi1;Chanhong Kim.
Chloroplast–nucleus communication takes place via processes called anterograde and retrograde signaling pathways. Discovery.of the retrograde signaling pathways from the chloroplasts to the nucleus also raised an intriguing proposition that.chloroplasts may serve as environmental sensors since multitudes of environmental factors disturb chloroplastic homeostasis..Certain chloroplastic perturbations, mostly impairing transcription/translation, are coupled to the repression of photosynthesis-.associated nuclear genes (PhANGs), thus finely coordinating photosynthetic and chloroplastic homeostasis. The unbiased.forward genetic screen in Arabidopsis leads to the identification of six independent loci called GENOMES UNCOUPLED.(GUN), whose inactivation was found to de-repress the expression of PhANGs under certain conditions promoting retrograde.signaling. Of the six GUNs, five encode proteins associated with tetrapyrrole biosynthesis and one, namely GUN1, encodes a.member of the pentatricopeptide repeat protein family. Despite the fact that GUN1 plays a role as a central signaling mediator.for retrograde communication, the molecular details of GUN1 protein still remain to be elucidated. Here, we recapitulate our.current understanding of the GUN1-mediated retrograde signaling pathway and propose a possible mode of action of GUN1.in the chloroplasts together with different aspects of GUN1 protein activity that deserve further investigation.
