Novel alternatives to reduce powder retention in the dry powder inhaler during aerosolization
Novel alternatives to reduce powder retention in the dry powder inhaler during aerosolization
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DOI：
10.1016/j.ijpharm.2013.05.006
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发表时间：
2013-08-16
影响因子：
5.8
通讯作者：
Tan, Reginald B. H.
中科院分区：
文献类型：
--
作者：
Heng, Desmond;Lee, Sie Huey;Tan, Reginald B. H.
干粉吸入器(DPI)主要用于通过将药物直接输送到肺部来治疗肺部疾病。药物输送效率通常很低，并且在DPI内有显著的药物滞留。一项旨在通过将残留药物引导到有用的吸入治疗成分中来最大限度地减少药物浪费的创新“绿色”倡议是先驱。通过在药物胶囊和输送装置上涂覆药学上可接受的力控制剂，可以最大限度地减少药物滞留。这种涂层降低了药物颗粒和DPI内表面之间的粘附性，从而使细颗粒剂量增加了高达300%。(C)2013爱思唯尔B.V.保留所有权利。
Dry powder inhalers (DPIs) are used predominantly for the treatment of pulmonary diseases by delivering drugs directly into the lungs. The drug delivery efficiency is typically low and there is significant drug retention inside the DPI. An innovative 'green' initiative aimed at minimizing drug wastage via channeling the residual drug into the useful inhaled therapeutic fraction was pioneered. Drug retention could be minimized via coating the drug capsule and delivery device with pharmaceutically acceptable force-control agents. This coating reduces the adhesion between the drug particles and the internal surfaces of the DPI, which in turn increases the fine particle dose by as much as 300%. (C) 2013 Elsevier B.V. All rights reserved.