Occlusion of the anterior cerebral artery after Gamma Knife irradiation in a rat.
Occlusion of the anterior cerebral artery after Gamma Knife irradiation in a rat.
复制标题
伽玛刀照射后大鼠大脑前动脉的闭塞。
DOI：
10.1007/bf01411289
复制
发表时间：
1996
影响因子：
2.4
通讯作者：
Steiner,L
中科院分区：
文献类型：
--
作者：
Kamiryo,T;Lopes,MB;Berr,SS;Lee,KS;Kassell,NF;Steiner,L
用伽玛刀照射大鼠大脑前动脉Willis环水平，最大剂量为25、50、100戈伊。在一只大鼠中观察到大脑前动脉闭塞，该大鼠在100戈伊照射后随访20个月。在中线额区和扣带回发现脑梗死。观察到动脉壁增厚伴纤维化、内弹性膜裂开、管腔机化血栓和平滑肌细胞迁移到血栓中。在大脑前动脉中，血栓形成似乎发生在内皮损伤之后，这可能在闭塞中起重要作用。在小动脉中，在辐照组织中观察到各种变化。这些包括纤维化和血栓，平滑肌层增厚，淋巴细胞浸润，血管壁增厚伴纤维化和纤维蛋白渗漏到周围组织中的纤维蛋白性血栓形成。这些变化与普通血管对损伤的反应相当，包括愈合性血管炎和动脉硬化。
The anterior cerebral artery of rats was irradiated at the level of the circle of Willis by Gamma Knife with a maximum dose of 25, 50, or 100 Gy. Occlusion of the anterior cerebral artery was observed in one rat which was followed for 20 months after irradiation of 100 Gy. Cerebral infarction was found at the midline-frontal region and the cingulate gyrus. Arterial wall thickening with fibrosis, splitting of the internal elastic membrane, luminal organized thrombus, and migration of smooth muscle cells into the thrombus were observed. In the anterior cerebral artery, thrombus formation seemed to occur after the endothelial injury and this may play a prominent role for occlusion. In small arteries, various changes were observed in the irradiated tissue. These included fibrosis and thrombus, thickened smooth muscle layer, lymphocytic infiltration, and thickening of vessel wall with fibrosis and fibrinous thrombosis with leakage of fibrin into the surrounding tissue after different doses of radiation and at different observation times. These changes were comparable to the ordinary vascular response to injury including healing vasculitis and arteriosclerosis.