Two-dimensional magnetic droplet manipulation platform for miniaturized bioanalytical applications
Two-dimensional magnetic droplet manipulation platform for miniaturized bioanalytical applications
复制标题
用于小型化生物分析应用的二维磁性液滴操纵平台
DOI:
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复制
发表时间:
2007
期刊:
影响因子:
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通讯作者:
M. Gijs
中科院分区:
文献类型:
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作者:
U. Lehmann;C. Vandevyver;V. K. Parashar;D. DeCourten;M. Gijs
We present a new approach for the manipulation of small liquid samples for the miniaturization of bioanalytical systems. In our system, minute liquid volumes are manipulated via the interaction of a changeable magnetic field and magnetic microparticles contained within aqueous droplets. Our setup enables the easy conversion of macroscopic bioanalytical protocols into the lab-on-a-chip format. Here we present the implementation of a DNA extraction and purification protocol as well as the on-chip optical detection of bioactive molecules. In both cases the miniaturization results in a decrease of the reaction and detection time as well as an increase in sensitivity.
影响因子:
2.9
作者:
Tian, HJ;Hühmer, AFR;Landers, JP
通讯作者:
Landers, JP