The dopaminergic modulation of fear: Quinpirole impairs the recall of emotional memories in rats
The dopaminergic modulation of fear: Quinpirole impairs the recall of emotional memories in rats
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DOI：
10.1037/0735-7044.113.1.152
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发表时间：
1999-02-01
影响因子：
1.9
通讯作者：
LeDoux, J
中科院分区：
文献类型：
--
作者：
Nader, K;LeDoux, J
过去研究多巴胺对恐惧的贡献产生了不一致的结果。目前的实验重新评估了这个问题。结果发现，系统预处理与D2激动剂quinpirole配对前2个条件刺激（CSs; CS2-CS 1）剂量依赖性地阻止收购的二级恐惧条件。Quinpirole的行动是不是由于非特异性损伤的能力，感知的CS，或形成和存储的协会，因为相同的药物预处理配对前相同的2 CS没有影响收购的感觉预处理。在另一项研究中，大鼠在未经治疗的情况下接受恐惧条件反射，然后在喹吡罗或其媒介物的影响下接受消退阶段。喹吡罗预处理阻断消光。研究结果表明，quinpirole减少恐惧，通过阻止检索的CS和无条件刺激（US）之间的学习关联，而不是贬值的美国，这将导致quinpirole的食欲与恐惧的厌恶属性的总和。
Past studies examining the contributions of dopamine to fear have produced inconsistent results. The present experiments reevaluated this issue. It was found that systemic pretreatment with the D2 agonist quinpirole before pairing 2 conditioned stimuli (CSs; CS2-CS1) dose dependently blocked the acquisition of second-order fear conditioning. Quinpirole's actions were not due to nonspecific impairments in the ability to perceive the CSs, or form and store an association, because the identical drug pretreatment before pairing the same 2 CSs had no effect on the acquisition of sensory preconditioning. In a separate study, rats were given fear conditioning while untreated and then received extinction sessions while under the influence of quinpirole or its vehicle. Quinpirole pretreatment blocked extinction. Findings suggest that quinpirole decreased fear by blocking the retrieval of a learned association between a CS and unconditioned stimulus (US), rather than by devaluing the US, which would have resulted from summation of quinpirole's appetitive properties with the aversive properties of fear.