An assessment of factors associated with quality of randomized controlled trials for smoking cessation
An assessment of factors associated with quality of randomized controlled trials for smoking cessation
复制标题
与戒烟随机对照试验质量相关的因素评估
DOI：
10.18632/oncotarget.10742
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Ren Zhewen
中科院分区：
文献类型：
--
作者：
Fan Hong;Song Fujian;Gu Hai;Wang Jianming;Jia Guizhen;Lu Moyuan;Qian Jiao;Wang Lei;Shen Jiemiao;Ren Zhewen
为了减少吸烟相关疾病，研究重点是开发有效的戒烟干预措施，而来自随机对照试验(RCT)的证据通常被认为是最有效的。然而，由于方法上的缺陷，随机对照试验的结果可能仍然具有误导性。本研究旨在评估41篇相关Cochrane系统评价(CSR)中1083篇戒烟干预措施的随机对照试验的质量。采用Logistic回归分析确定与随机对照试验质量相关的显著变量。研究发现，随机对照试验戒烟的证据主要来自高收入国家，只有8.6%的随机对照试验的总体质量很高。高质量的随机对照研究往往具有较大的样本量，而且是在属于不同收入类别的多个国家进行的，发表的时间较晚。总而言之，戒烟干预措施的随机对照试验的总体质量还远远不够完美，欠发达国家需要更多的随机对照试验为全球烟草控制提供高质量的证据。应该鼓励发达国家和欠发达国家的研究人员之间的合作。
To reduce smoking-related diseases, a research priority is to develop effective interventions for smoking cessation, and evidence from randomized controlled trials (RCTs) is usually considered to be the most valid. However, findings from RCTs may still be misleading due to methodological flaws. This study aims to assess the quality of 1083 RCTs of smoking cessation interventions in 41 relevant Cochrane Systematic Reviews (CSRs). Logistic regression analysis was performed to identify significant variables associated with the quality of RCTs. It was found that evidence for smoking cessation from RCTs was predominantly from high income countries, and the overall quality was high in only 8.6% of the RCTs. High quality RCTs tended to have a larger sample size, to be more recently published, and conducted in multiple countries belonging to different income categories. In conclusion, the overall quality of RCTs of smoking cessation interventions is far from perfect, and more RCTs in less developed countries are required to generate high grade evidence for global tobacco control. Collaboration between researchers in developed and less developed countries should be encouraged.
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影响因子：
8.4
作者：
Carr, Alan B.;Ebbert, Jon
通讯作者：
Ebbert, Jon
影响因子：
7.2
作者：
Guyatt, Gordon H.;Oxman, Andrew D.;Schuenemann, Holger J.
通讯作者：
Schuenemann, Holger J.
DOI：
10.1002/14651858.cd002928.pub4
发表时间：
2018-08-13
期刊：
The Cochrane database of systematic reviews
影响因子：
--
作者：
Faseru B;Richter KP;Scheuermann TS;Park EW
通讯作者：
Park EW
影响因子：
2.6
作者：
Jones AC;Geneau R
通讯作者：
Geneau R
影响因子：
1.4
作者：
Cahill, Kate;Stead, Lindsay F.;Polonio, Igor Bastos
通讯作者：
Polonio, Igor Bastos