Constitutional Rho-Kinase Regulates Atrioventricular Nodal Conduction and Ventricular Repolarization of the Canine Heart
Constitutional Rho-Kinase Regulates Atrioventricular Nodal Conduction and Ventricular Repolarization of the Canine Heart
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体质性 Rho 激酶调节犬心脏的房室结传导和心室复极
DOI：
10.1097/00005344-200306000-00015
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发表时间：
2003
影响因子：
3
通讯作者：
K. Hashimoto
中科院分区：
文献类型：
--
作者：
A. Sugiyama;A. Takahara;Y. Yatomi;Y. Satoh;Yuji Nakamura;K. Hashimoto
鉴于有限的信息，Rho激酶在心脏传导系统和心室复极过程中的生理作用进行了评估，并与冠状动脉血管张力进行了比较。在心室单相动作电位监测下，将特异性Rho激酶抑制剂Y-27632给予犬离体血液灌注房室结制备物的营养冠状动脉。Y-27632给药中度抑制房室结传导，轻微但显著加速复极过程，并有效增加冠状动脉血流量，而几乎不影响心室内传导。引起目前观察到的效应的Y-27632的估计浓度足以抑制Rho激酶。这些结果表明，宪法Rho激酶的功能，适度地促进房室结传导，轻微延迟心室复极过程，并显着增加冠状动脉血管张力。
Given the limited information, physiological roles of Rho-kinase in the cardiac conduction system and ventricular repolarization process were assessed in comparison with those in the coronary vascular tone. A specific Rho-kinase inhibitor Y-27632 was administered to the nutrient coronary artery of the canine isolated, blood-perfused atrioventricular node preparation under the monitoring of the ventricular monophasic action potentials. Administration of Y-27632 moderately suppressed the atrioventricular nodal conduction, slightly but significantly accelerated the repolarization process, and potently increased the coronary blood flow, whereas it hardly affected the intraventricular conduction. The estimated concentrations of Y-27632 causing the currently observed effects were enough to inhibit Rho-kinase. These results suggest that constitutional Rho-kinase functions to moderately facilitate the atrioventricular nodal conduction, slightly delay ventricular repolarization process, and significantly increase the coronary vascular tone.
影响因子：
15.9
作者：
Sah, VP;Minamisawa, S;Brown, JH
通讯作者：
Brown, JH