Cerebrospinal fluid hypocretin-1 (orexin A) levels in mania compared to unipolar depression and healthy controls
Cerebrospinal fluid hypocretin-1 (orexin A) levels in mania compared to unipolar depression and healthy controls
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DOI：
10.1016/j.neulet.2010.07.038
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发表时间：
2010-10
影响因子：
2.5
通讯作者：
F. Schmidt;M. Brügel;J. Kratzsch;M. Strauss;C. Sander;P. Baum;J. Thiery;U. Hegerl;P. Schönknecht
中科院分区：
文献类型：
--
作者：
F. Schmidt;M. Brügel;J. Kratzsch;M. Strauss;C. Sander;P. Baum;J. Thiery;U. Hegerl;P. Schönknecht
背景发作性睡病以下丘脑泌素（hcrt）或其受体缺乏为特征，存在睡眠-觉醒周期和昼夜节律障碍。在情感性精神障碍如重度抑郁症和躁狂症中也发现了一种基于脑电图（EEG）的警觉调节紊乱。本研究首次对躁狂发作患者的hcrt水平进行了研究，并与年龄匹配的MDD患者和对照组进行了比较。5躁狂（平均YMRS 15.6±2.9）和5名年龄匹配的MDD患者（平均HDRS 11.6±8.0），以及5名年龄匹配的无任何神经或精神障碍的对照。结果躁狂症患者脑脊液hcrt-1水平（77.3±20.7pg/ml）与MDD患者（75.6±15.7pg/ml）及对照组（74.9±19.3pg/ml）比较，差异无显著性（P> 0.05）。Hcrt水平和疾病的严重程度没有表现出显着association.ConclusionIn本研究中，第一次hcrt-1水平在躁狂患者进行了调查，但没有发现显着差异，无论是与年龄匹配的MDD患者，也没有任何精神或神经系统疾病的健康对照组。
BackgroundImpairment of sleep–wake cycles and circadian rhythm are found in human narcolepsy which is characterized by deficiency of hypocretin (hcrt) or its receptors. A disturbed electroencephalography (EEG) based vigilance regulation is also found in affective disorders such as major depressive disorder (MDD) and mania. For the first time, in the present study hcrt levels were investigated in patients with a manic episode and compared with age-matched patients with MDD and controls.Methods15 subjects were enrolled in the study after admission to hospital: 5 manic (mean YMRS 15.6±2.9) and 5 age-matched patients with MDD (mean HDRS 11.6±8.0), and 5 age-matched controls without any neurological or psychiatric disorder. Cerebrospinal fluid (CSF) hcrt levels were measured in all three groups using a fluorescence immunoassay (FIA).ResultsMean hcrt-1 level in manic patients (77.3±20.7pg/ml) did not differ significantly compared to patients with MDD (75.6±15.7pg/ml MDD) or controls (74.9±19.3pg/ml). Hcrt levels and severity of disease did not show a significant association.ConclusionIn the present study, for the first time hcrt-1 levels in manic patients were investigated but did not reveal significant differences neither compared to age-matched patients with MDD nor healthy controls without any psychiatric or neurological disorder.