Perceptions of and interest in HIV pre-exposure prophylaxis use among adolescent girls and young women in Lilongwe, Malawi
Perceptions of and interest in HIV pre-exposure prophylaxis use among adolescent girls and young women in Lilongwe, Malawi
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DOI：
10.1371/journal.pone.0226062
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发表时间：
2020-01-13
期刊：
影响因子：
3.7
通讯作者：
Rosenberg, Nora E.
中科院分区：
文献类型：
--
作者：
Maseko, Bertha;Hill, Lauren M.;Rosenberg, Nora E.
口服暴露前预防（Oral Pre-Exposure Prephylaxis，PrEP）是一种有效的HIV预防策略。撒哈拉以南非洲的少女和年轻妇女（AGYW）可能特别受益于PrEP，因为这一群体的艾滋病毒负担不成比例。了解潜在用户的看法和兴趣，使用准备是至关重要的，以促进利用准备的个人在艾滋病毒的风险。MethodsThis定性调查AGYW的知识和兴趣的准备使用的背景下进行的女孩权力，准实验队列研究比较四种模式的服务提供在马拉维利隆圭的四个卫生中心。我们对40名年龄在15-24岁之间的艾滋病毒阴性AGYW进行了个人深入访谈（IDIs）。向参与者提供了PrEP的解释。访谈主题包括参与者的先验知识，兴趣，关注，和交付偏好为PrEP。分析包括结构编码的访谈成绩单对应的访谈主题，这些主题内的响应摘要，并确定和描述每个主题内的新兴主题。ResultsNone of the AGYW had knowledge of PrEP before the IDIs，but once explained，大多数人表示有兴趣使用避孕套，原因是避孕套使用不一致、避孕套使用错误、他们自己或他们的伴侣同时存在性伙伴关系以及强奸。大多数女青年协会希望在卫生中心的青年友好部门提供PrEP，以方便获得和青年友好咨询。他们建议需要单独包装PrEP以确保用户隐私。对关系不稳定和滥交的指控提出了作为潜在的障碍use.ConclusionGeneral兴趣在准备AGYW之间是高的。离散包装和获得青年友好的PrEP交付方式可能有助于利用PrEP作为性活跃AGYW之间的预防策略。在向这一人群引入PrEP时，需要注意合作伙伴和社区成员对PrEP使用的潜在负面反应。
BackgroundOral Pre-Exposure Prophylaxis (PrEP) is an effective HIV prevention strategy for adherent users. Adolescent girls and young women (AGYW) in sub-Saharan Africa may particularly benefit from PrEP because of the disproportionate burden of HIV in this group. Understanding potential users' perceptions of and interest in using PrEP is critical to promote the utilization of PrEP by individuals at risk of HIV.MethodsThis qualitative investigation of AGYW's knowledge of and interest in PrEP use was conducted in the context of Girl Power, a quasi-experimental cohort study comparing four models of service delivery at four health centers in Lilongwe, Malawi. We conducted individual in-depth interviews (IDIs) with 40 HIV-negative AGYW ages 15-24 years old six months after enrolment in the parent study. An explanation of PrEP was provided to participants. Interview topics included participants' prior knowledge of, interest in, concerns about, and delivery preferences for PrEP. Analysis consisted of structural coding of interview transcripts corresponding to interview topics, summary of responses within these topics, and identification and description of emerging themes within each topic.ResultsNone of the AGYW had knowledge of PrEP prior to the IDIs, but once explained, a majority expressed an interest in using it due to inconsistencies in condom use, condom use errors, their own or their partners' concurrent sexual partnerships, and rape. Most AGYW hoped that PrEP would be available in youth-friendly sections of health centers for easy access and youth-friendly counselling. They suggested that discrete packaging of PrEP would be needed to ensure user privacy. Concerns about relationship destabilization and accusations of promiscuity were raised as potential barriers to use.ConclusionGeneral interest in PrEP among AGYW was high. Discrete packaging and access to youth-friendly PrEP delivery modalities may facilitate the utilization of PrEP as a prevention strategy among sexually active AGYW. Attention to potential negative reactions from partners and community members to PrEP use will be needed when introducing PrEP to this population.