β-クリプトキサンチンと生活習慣病予防：最近の疫学研究から
β-クリプトキサンチンと生活習慣病予防：最近の疫学研究から
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β-隐黄质与生活方式相关疾病的预防：来自最近的流行病学研究
DOI：
10.1248/yakushi.14-00208-5
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发表时间：
2015
影响因子：
0.3
通讯作者：
M. Sugiura
中科院分区：
文献类型：
--
作者：
M. Sugiura
抗氧化微量营养素，如维生素和类胡萝卜素，在水果和蔬菜中大量存在，并且已知有助于身体防御活性氧。最近的许多流行病学研究表明，富含类胡萝卜素或血清类胡萝卜素浓度高的水果和蔬菜的饮食消费量高，导致某些癌症，糖尿病和心血管疾病的风险降低。这些流行病学研究表明，抗氧化剂类胡萝卜素可能对几种与生活方式有关的疾病具有保护作用。β-隐黄质（β-Cryptoxanthin）是日本柑橘（Citrus unshiu MARC.）水果，主要产于日本。我们的营养流行病学调查，米卡比研究，利用来自健康检查的居民在静冈，日本的米卡比镇。在这项调查中，我们测量了血清β-隐黄质作为一种特定的生物标志物，以估计日本柑橘水果的消费量。从Mikkabi研究的横断面分析中，我们发现血清β-隐黄素与动脉粥样硬化、胰岛素抵抗、肝功能障碍、代谢综合征、低骨密度和氧化应激的风险呈负相关。本文综述了近年来关于血清β-隐黄素与几种生活方式相关疾病风险之间关系的流行病学研究。
Antioxidant micronutrients, such as vitamins and carotenoids, exist in abundance in fruits and vegetables and have been known to contribute to the body's defense against reactive oxygen species. Numerous recent epidemiologic studies have demonstrated that a high dietary consumption of fruit and vegetables rich in carotenoids or with high serum carotenoid concentrations results in lower risks of certain cancers, diabetes, and cardiovascular disease. These epidemiologic studies have suggested that antioxidant carotenoids may have a protective effect against several lifestyle-related diseases. β-Cryptoxanthin is a carotenoid pigment found in Japanese mandarin (Citrus unshiu MARC.) fruit, which is mainly produced in Japan. Our nutritional epidemiologic survey, the Mikkabi Study, utilized data derived from health examinations of inhabitants performed in the town of Mikkabi in Shizuoka, Japan. In this survey, we measured serum β-cryptoxanthin as a specific biomarker to estimate the consumption of Japanese mandarin fruit. From the cross-sectional analyses from the Mikkabi Study, we found inverse associations of serum β-cryptoxanthin with the risks for atherosclerosis, insulin resistance, liver dysfunction, metabolic syndrome, low bone mineral density, and oxidative stress. In this review, recent epidemiologic studies about the associations between serum β-cryptoxanthin with the risk for several lifestyle-related diseases were reviewed.