Molecular subtypes of breast carcinoma in Egyptian women: Clinicopathological features
Molecular subtypes of breast carcinoma in Egyptian women: Clinicopathological features
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DOI：
10.1016/j.prp.2012.03.011
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发表时间：
2012-01-01
影响因子：
2.8
通讯作者：
Zalata, Khaled R.
中科院分区：
文献类型：
--
作者：
El-Hawary, Amira K.;Abbas, Ahmed S.;Zalata, Khaled R.
乳腺癌可根据雌激素、孕激素和Her-2/neu受体的免疫组织化学标记物分为不同的分子亚型。本研究的目的是确定本地区乳腺癌分子亚型的临床病理学特征。从埃及曼苏拉KRZ博士转诊病理学实验室和曼苏拉大学病理学系的文件中选择了274例手术切除的乳腺癌。分子亚型分为管腔型A、管腔型B、Her-2/neu表达型和三阴性。分子亚型的临床病理和组织学特征分析显示，管腔A型最常见（41.2%），其次为三阴性（28.5%），Her 2表达型（19.4%）和管腔B型（13.9%）。最常见的组织学类型为浸润性导管癌（83.2%），其次为浸润性小叶癌（9.1%）和髓样癌（3.2%）。管腔A亚型是显着相关的低肿瘤等级，阳性淋巴结转移，没有坏死和合胞体生长pattern.We的最常见的分子亚型的浸润性乳腺癌埃及妇女之间的管腔亚型A，表现出良好的功能。三阴性亚型和髓样癌的比例高于西方国家。(c)2012 Elsevier GmbH. All rights reserved.
Breast carcinoma may be classified into distinct molecular subtypes based on immunohistochemical markers for estrogen, progesterone and Her-2/neu receptors. The aim of the study was to identify the clinicopathological features of the molecular subtypes of breast carcinoma in our locality.A total of 274 surgically resected breast carcinomas were selected from the files of the Dr. KRZ referral pathology laboratory, Mansoura, Egypt, and the Pathology Department of Mansoura University. Molecular subtypes were classified into luminal A, luminal B, Her-2/neu-expressing and triple-negative. Clinicopathological and histological features of molecular subtypes were analyzed.Luminal A subtype was the most prevalent (41.2%), followed by triple-negative subtype (28.5%), then Her2-expressing subtype (19.4%) and luminal B subtype (13.9%). The commonest histological type was infiltrating duct carcinoma (83.2%), followed by infiltrating lobular carcinoma (9.1%) and medullary carcinoma (3.2%). The luminal A subtype was significantly correlated to low tumor grade, lower number of positive lymph nodes metastasis, absence of both necrosis and syncytial growth pattern.We concluded that the commonest molecular subtype of invasive breast carcinoma among Egyptian women is luminal subtype A, which displayed favorable features. Triple-negative subtype and medullary carcinomas are present in a ratio higher than in western countries. (c) 2012 Elsevier GmbH. All rights reserved.