Fixed Subaortic Stenosis: A Clinical Dilemma for Clinicians and Patients
Fixed Subaortic Stenosis: A Clinical Dilemma for Clinicians and Patients
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DOI：
10.1111/chd.12127
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发表时间：
2013-09-01
影响因子：
0.3
通讯作者：
Ezon, David S.
中科院分区：
文献类型：
--
作者：
Ezon, David S.
主动脉瓣下狭窄具有相当高的发病率和死亡率。在大多数情况下，患者存在潜在的左心室流出道形态，可促进流出道湍流，从而诱导主动脉下纤维肌组织的发育。一部分患者将发展为严重狭窄和主动脉瓣返流，但很难确定哪些患者有风险。虽然切除主动脉下组织可改善即刻疗效，但许多患者的狭窄和返流均复发，质疑外科干预对无症状患者的疗效。这篇综述文章描述了目前对主动脉瓣下狭窄的病因、治疗和预后的了解。
Subaortic stenosis carries considerable morbidity and mortality. In most cases, patients have an underlying left ventricular outflow tract morphology that promotes turbulence at the outflow tract, which induces the development of subaortic fibromuscular tissue. A subset of patients will progress to develop severe stenosis and aortic regurgitation, but it has been difficult to determine which patients are at risk. While resection of the subaortic tissue improves immediate outcome, many patients have recurrence of both stenosis and regurgitation, questioning the efficacy of surgical intervention in asymptomatic patients. This review article describes the current understanding of the etiology, treatment, and prognosis of subaortic stenosis.