MORTALITY AND INDUSTRIAL-HYGIENE STUDY OF WORKERS EXPOSED TO POLYCHLORINATED-BIPHENYLS
MORTALITY AND INDUSTRIAL-HYGIENE STUDY OF WORKERS EXPOSED TO POLYCHLORINATED-BIPHENYLS
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DOI：
10.1080/00039896.1981.10667615
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
JONES, M
中科院分区：
文献类型：
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作者：
BROWN, DP;JONES, M
由于暴露于多氯联苯（PCB）对动物的毒性效应已得到证实，国家职业安全和健康研究所[美国]对两个工厂的2567名工人进行了一项回顾性队列死亡率研究，其中PCB用于制造电容器。所有工人至少受雇3个月。在使用多氯联苯的工厂区域。确定了2个队列中98%的生命状态，累计39，018人-年。全因死亡率低于预期（163 obs [观察] vs. 182.4 exp [预期]）和所有癌症死亡率（39 obs vs. 43.8 exp）。观察到直肠癌（4 obs vs. 1.19 exp）和肝癌（3 obs vs. 1.07 exp）的死亡率过高，但两者均无统计学显著性差异。在1株植物中，观察到由于肝硬化导致的死亡率也升高。还介绍了在每个工厂进行的详细工业卫生调查的结果。
Because of the demonstrated toxic effects on animals resulting from exposure to polychlorinated biphenyls (PCB), the National Institute for Occupational Safety and Health [USA] conducted a retrospective cohort mortality study of 2567 workers in 2 plants where PCB were used in the manufacture of electrical capacitors. All workers were employed for at least 3 mo. in areas of the plants where PCB were used. The vital status of 98% of the 2 cohorts was determined and 39,018 person-yr were accumulated. All-cause mortality was lower than expected (163 obs [observed] vs. 182.4 exp [expected]) and all cancer mortality (39 obs vs. 43.8 exp). Excess mortality was noted for rectal cancer (4 obs vs. 1.19 exp) and liver cancer (3 obs vs. 1.07 exp), although neither excess was statistically significant. In 1 plant observed mortality due to cirrhosis of the liver was also elevated. The results of detailed industrial hygiene surveys conducted in each plant were also presented.