Invasive cervical cancer and combined oral contraceptives. WHO collaborative study of neoplasia and steroid contraceptives.
Invasive cervical cancer and combined oral contraceptives. WHO collaborative study of neoplasia and steroid contraceptives.
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侵袭性宫颈癌和复方口服避孕药。
DOI：
10.1136/bmj.290.6473.961
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
D. Roseman
中科院分区：
文献类型：
--
作者：
D. Thomas;A. Whitehead;D. Roseman
在世界卫生组织的主持下，正在进行一项多中心、以医院为基础的病例对照研究，以确定类固醇避孕药是否会改变妇科、乳腺和肝脏肿瘤的风险。主要来自发展中国家的关于复方口服避孕药与浸润性宫颈癌之间关系的初步结果显示，曾使用过口服避孕药的妇女的相对风险为1.19（95%置信区间为0.99-1.44）。风险随着使用时间的增加而增加，五年后的相对风险为1.53。这一发现支持了因果解释，但也可能是由于对混杂性变量和其他偏见来源的控制不完全。
A multicentre, hospital based case-control study is being conducted under the auspices of the World Health Organisation to determine whether steroid contraceptives alter the risk of gynaecological, breast, and hepatic neoplasms. Preliminary results, largely from developing countries, on the relation between combined oral contraceptives and invasive cervical carcinoma showed a relative risk of 1.19 (95% confidence interval 0.99-1.44) in women who had ever used oral contraceptives. The risk increased with duration of use, giving a relative risk of 1.53 after five years. This finding supports a causal interpretation, but it could also be due to incomplete control for confounding sexual variables and other sources of bias.