Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase
Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase
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DOI：
10.1016/j.bmcl.2016.02.021
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发表时间：
2016-03-15
影响因子：
2.7
通讯作者：
Carson, Kenneth G.
中科院分区：
文献类型：
--
作者：
Tarver, James E., Jr.;Pabba, Praveen K.;Carson, Kenneth G.
A group of small molecule thienopyrimidine inhibitors of Notum Pectinacetylesterase are described. We explored both 2-((5,6-thieno[2,3-d]pyrimidin-4-yl)thio)acetic acids and 2-((6,7-thieno[3,2-d]pyrimidin-4-yl)thio)acetic acids. In both series, highly potent, orally active Notum Pectinacetylesterase inhibitors were identified. (C) 2016 Elsevier Ltd. All rights reserved.
