The granuloma in cryptococcal disease.
The granuloma in cryptococcal disease.
复制标题
隐球菌病中的肉芽肿。
DOI：
10.1371/journal.ppat.1009342
复制
发表时间：
2021-03
期刊：
影响因子：
6.7
通讯作者：
Davis JM
中科院分区：
文献类型：
--
作者：
Ristow LC;Davis JM
尽管我们认识到隐球菌病是一种疾病已有100多年的历史，但关于其发病机制仍有许多细节尚不清楚。更好地了解隐球菌感染的一个主要障碍是隐球菌感染可能采取的非常广泛的临床和病理形式。一种这样的形式在历史上被称为隐球菌肉芽肿，或隐球菌瘤。这些词基本上被用来描述任何与感染有关的肿块病变，因为它们被认为与典型的肉芽肿相似，即结核病中的结节。尽管已经发现了结核病和隐球菌病之间的明显区别，但细胞和分子研究仍然证实了这两种疾病和我们现在所说的肉芽肿性炎症之间的一些重要相似之处。在这篇综述中，我们将勾勒出“肉芽肿”这个术语背后的一些历史，因为它与隐球菌疾病有关，探索我们目前对肉芽肿形成生物学的理解，并试图将这种理解放在这种感染的无数病理表现的背景下。最后，我们将总结肉芽肿在隐球菌潜伏期中的作用，并为未来的研究提供机会。
Although we have recognized cryptococcosis as a disease entity for well over 100 years, there are many details about its pathogenesis which remain unknown. A major barrier to better understanding is the very broad range of clinical and pathological forms cryptococcal infections can take. One such form has been historically called the cryptococcal granuloma, or the cryptococcoma. These words have been used to describe essentially any mass lesion associated with infection, due to their presumed similarity to the quintessential granuloma, the tubercle in tuberculosis. Although clear distinctions between tuberculosis and cryptococcal disease have been discovered, cellular and molecular studies still confirm some important parallels between these 2 diseases and what we now call granulomatous inflammation. In this review, we shall sketch out some of the history behind the term “granuloma” as it pertains to cryptococcal disease, explore our current understanding of the biology of granuloma formation, and try to place that understanding in the context of the myriad pathological presentations of this infection. Finally, we shall summarize the role of the granuloma in cryptococcal latency and present opportunities for future investigations.
登录
查看更多内容
影响因子：
4.4
作者：
Lindell, Dennis M.;Ballinger, Megan N.;Huffnagle, Gary B.
通讯作者：
Huffnagle, Gary B.
影响因子：
8
作者：
Goldman, DL;Khine, H;Casadevall, A
通讯作者：
Casadevall, A
影响因子：
4
作者：
Grebenciucova, Elena;Reder, Anthony T.;Bernard, Jacqueline T.
通讯作者：
Bernard, Jacqueline T.
影响因子：
6.4
作者：
Alanio, Alexandre;Vernel-Pauillac, Frederique;Dromer, Francoise
通讯作者：
Dromer, Francoise
影响因子：
2.8
作者：
McQuiston, Travis;Luberto, Chiara;Del Poeta, Maurizio
通讯作者：
Del Poeta, Maurizio