TNF autovaccination induces self anti-TNF antibodies and inhibits metastasis in a murine melanoma model.
TNF autovaccination induces self anti-TNF antibodies and inhibits metastasis in a murine melanoma model.
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DOI：
10.1038/sj.bjc.6601670
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发表时间：
2004-03-22
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
TNF is a proinflammatory cytokine involved in the pathogenesis of chronic inflammatory diseases, but also in metastasis in certain types of cancer. In terms of therapy, TNF is targeted by anti-TNF neutralising monoclonal antibodies or soluble TNF receptors. Recently, a novel strategy based on the generation of self anti-TNF antibodies (TNF autovaccination) has been developed. We have previously shown that TNF autovaccination successfully generates high anti-TNF antibody titres, blocks TNF and ameliorates collagen-induced arthritis in DBA/1 mice. In this study, we examined the ability of TNF autovaccination to generate anti-TNF antibody titres and block metastasis in the murine B16F10 melanoma model. We found that immunisation of C57BL/6 mice with TNF autovaccine produces a 100-fold antibody response to TNF compared to immunisation with phosphate-buffered saline vehicle control and significantly reduces both the number (P<0.01) and size of metastases (P<0.01) of B16F10 melanoma cells. This effect is also observed when an anti-TNF neutralising monoclonal antibody is administered, confirming the essential role TNF plays in metastasis in this model. This study suggests that TNF autovaccination is a cheaper and highly efficient alternative that can block TNF and reduce metastasis in vivo and trials with TNF autovaccination are already underway in patients with metastatic cancer.
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影响因子：
3.7
作者：
Sarawar, SR;Lee, BJ;Von Gesjen, S
通讯作者：
Von Gesjen, S
影响因子：
82.9
作者：
Moore, RJ;Owens, DM;Balkwill, F
通讯作者：
Balkwill, F
影响因子：
46.9
作者：
Dalum, I;Butler, DM;Mouritsen, S
通讯作者：
Mouritsen, S
DOI：
10.1084/jem.177.5.1391
发表时间：
1993-05-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Orosz P;Echtenacher B;Falk W;Rüschoff J;Weber D;Männel DN
通讯作者：
Männel DN
影响因子：
6.4
作者：
Harmey, JH;Bucana, CD;Dong, ZY
通讯作者：
Dong, ZY