Depression is associated with the metabolic syndrome among patients with type 1 diabetes
Depression is associated with the metabolic syndrome among patients with type 1 diabetes
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DOI：
10.3109/07853890.2010.503660
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发表时间：
2010-10-01
影响因子：
4.4
通讯作者：
Groop, Per-Henrik
中科院分区：
文献类型：
--
作者：
Ahola, Aila J.;Thorn, Lena M.;Groop, Per-Henrik
背景抑郁症和代谢综合征在1型糖尿病患者中经常发现，但它们之间的潜在联系尚未得到研究。本文旨在探讨1型糖尿病患者抑郁与代谢综合征的关系。2003年至2009年期间，共有1226名患者参加了芬兰糖尿病肾病研究。抑郁症被定义为使用抗抑郁药物或贝克抑郁量表（BDI）评分>= 16。代谢综合征的定义采用国际糖尿病联盟流行病学和预防工作组（IDF）、国家心肺血液研究所（NHLBI）、美国心脏协会（AHA）、世界心脏联盟（WHF）、国际动脉粥样硬化协会（IAS）和国际肥胖研究协会（IASO）制定的标准。代谢综合征在抑郁症患者中更常见（57%比46%，P = 0.008）。在代谢综合征的各个组成部分中，腰围、甘油三酯和HDL组成部分在抑郁症患者中更常见。BDI评分随着代谢综合征组分数量的增加而增加。当校正性别、年龄、社会经济状况、吸烟、肾病和HbA时，BDI评分与腰围独立相关（比值比1.03，95%置信区间1.01-1.05
Background. Both depression and the metabolic syndrome are frequently found among patients with type 1 diabetes, but their potential association has not yet been investigated. In this paper the relationship between depression and the metabolic syndrome among patients with type 1 diabetes was evaluated.Methods. A total of 1226 patients participating in the Finnish Diabetic Nephropathy Study between 2003 and 2009 were included. Depression was defined as use of antidepressive medication or Beck Depression Inventory (BDI) score >= 16. The metabolic syndrome was defined using the criteria established by the International Diabetes Federation Task Force on Epidemiology and Prevention (IDF); National Heart, Lung, and Blood Institute (NHLBI); American Heart Association (AHA); World Heart Federation (WHF); International Atherosclerosis Society (IAS); and International Association for the Study of Obesity (IASO).Results. The metabolic syndrome was more frequently observed among depressed patients (57% versus 46%, P = 0.008). Of the individual components of the metabolic syndrome, waist, triglyceride, and HDL components were more frequently fulfilled among patients with depression. The BDI score increased with the number of components of the metabolic syndrome present. The BDI score was independently associated with the waist component (odds ratio 1.03, 95% confidence interval 1.01-1.05) when adjusted for gender, age, socio-economic status, smoking, nephropathy, and HbA