Association between Intraocular Pressure and Rates of Retinal Nerve Fiber Layer Loss Measured by Optical Coherence Tomography.
Association between Intraocular Pressure and Rates of Retinal Nerve Fiber Layer Loss Measured by Optical Coherence Tomography.
复制标题
DOI：
10.1016/j.ophtha.2016.07.006
复制
发表时间：
2016-10
期刊：
影响因子：
13.7
通讯作者：
Medeiros FA
中科院分区：
文献类型：
--
作者：
Diniz-Filho A;Abe RY;Zangwill LM;Gracitelli CP;Weinreb RN;Girkin CA;Liebmann JM;Medeiros FA
评估眼压 (IOP) 与通过谱域 (SD) 光学相干断层扫描 (OCT) 测量的视网膜神经纤维层 (RNFL) 厚度随时间变化率之间的关系。观察性队列研究。该研究涉及 339 名患者的 547 只眼睛，随访时间平均为 3.9 ± 0.9 年。 308 人 (56.3%) 被诊断为青光眼，239 人 (43.7%) 被认为患有青光眼。所有眼睛均使用 Spectralis® SD OCT（德国海德堡海德堡工程有限公司）进行成像，并进行眼压测量和标准自动视野检查 (SAP)。青光眼进展被定义为 SAP Guided Progression Analysis™ 软件的“可能进展”结果。使用线性混合模型研究随访期间平均眼压与 RNFL 厚度变化率之间的关系，同时考虑潜在的混杂因素，如年龄、种族、角膜厚度和基线疾病严重程度。 IOP 与通过 SD OCT 测量的整体和局部 RNFL 厚度损失率之间的关联。 46 只眼睛 (8.4%) 在随访期间显示 SAP 进展。 SAP 进展的眼睛的整体 RNFL 厚度变化率比未进展的眼睛更快（分别为 -1.02 µm/年和 -0.61 µm/年；P = 0.002）。对于进展的眼睛，随访期间平均眼压每升高 1 mmHg，平均眼压就会增加 0.20 µm/年 [置信区间 (CI)：0.08 至 0.31 µm/年；总体 RNFL 厚度 P < 0.001]，而非进展眼仅为 0.04 µm/年（CI：0.01 至 0.07 µm/年；P = 0.015）。 IOP 和 RNFL 变化率之间的最大关联出现在颞上区和颞下区的测量中，而最小的关联出现在鼻区的测量中。随访期间较高的 IOP 水平与 SD OCT 测量的随时间推移 RNFL 丢失速度较快相关。这些发现支持使用 SD OCT RNFL 厚度测量作为生物标志物来评估降低 IOP 的疗法减缓疾病进展速度的功效。在一项纵向研究中，通过谱域光学相干断层扫描测量，随访期间较高的眼压水平与随着时间的推移青光眼视网膜神经纤维层损失的速度更快相关。
To evaluate the relationship between intraocular pressure (IOP) and rates of retinal nerve fiber layer (RNFL) thickness change over time measured by spectral-domain (SD) optical coherence tomography (OCT). Observational cohort study. The study involved 547 eyes of 339 patients followed for an average period of 3.9 ± 0.9 years. Three hundred and eight (56.3%) had a diagnosis of glaucoma and 239 (43.7%) were considered glaucoma suspects. All eyes underwent imaging using the Spectralis® SD OCT (Heidelberg Engineering GmbH, Heidelberg, Germany), along with IOP measurements and standard automated perimetry (SAP). Glaucoma progression was defined as a result of “Likely Progression” from the Guided Progression Analysis™ software for SAP. Linear mixed models were used to investigate the relationship between average IOP during follow-up and rates of RNFL thickness change, while taking into account potential confounding factors, such as age, race, corneal thickness, and baseline disease severity. The association between IOP and rates of global and sectorial RNFL thickness loss measured by SD OCT. Forty-six eyes (8.4%) showed progression on SAP during follow-up. Rates of global RNFL thickness change in eyes that progressed by SAP were faster than in those that did not progress (−1.02 µm/year versus −0.61 µm/year, respectively; P = 0.002). For progressing eyes, each 1 mmHg higher average IOP during follow-up was associated with an additional average loss of 0.20 µm/year [confidence interval (CI): 0.08 to 0.31 µm/year; P < 0.001] of global RNFL thickness versus only 0.04 µm/year (CI: 0.01 to 0.07 µm/year; P = 0.015) for non-progressing eyes. The largest associations between IOP and rates of RNFL change were seen for measurements from the temporal superior and temporal inferior sectors, whereas the smallest association was seen for measurements from the nasal sector. Higher levels of IOP during follow-up were associated with faster rates of RNFL loss over time measured by SD OCT. These findings support the use of SD OCT RNFL thickness measurements as biomarkers for the evaluation of the efficacy of IOP-lowering therapies to slow down the rate of disease progression. In a longitudinal study, higher levels of intraocular pressure during follow-up were associated with faster rates of glaucomatous retinal nerve fiber layer loss over time measured by spectral-domain optical coherence tomography.
登录
查看更多内容
影响因子：
4.4
作者：
Medeiros FA;Zangwill LM;Alencar LM;Bowd C;Sample PA;Susanna R Jr;Weinreb RN
通讯作者：
Weinreb RN
影响因子：
13.7
作者：
Medeiros, Felipe A.;Gracitelli, Carolina P. B.;Boer, Erwin R.;Weinreb, Robert N.;Zangwill, Linda M.;Rosen, Peter N.
通讯作者：
Rosen, Peter N.
影响因子：
13.7
作者：
Leske, M. Cristina;Heijl, Anders;Yang, Zhongming
通讯作者：
Yang, Zhongming
DOI：
10.1136/bjophthalmol-2014-305550
发表时间：
2015-05
期刊：
The British journal of ophthalmology
影响因子：
--
作者：
Medeiros FA
通讯作者：
Medeiros FA
影响因子：
--
作者：
Medeiros, Felipe A.;Alencar, Luciana M.;Zangwill, Linda M.;Bowd, Christopher;Sample, Pamela A.;Weinreb, Robert N.
通讯作者：
Weinreb, Robert N.