Protecting the kidney during critical illness
Protecting the kidney during critical illness
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DOI：
10.1097/aco.0b013e328013f83c
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发表时间：
2007-04-01
影响因子：
2.5
通讯作者：
Lee, H. Thomas
中科院分区：
文献类型：
--
作者：
Jones, Dean R.;Lee, H. Thomas
综述目的急性肾功能衰竭在危重患者中引起相当大的发病率和死亡率。迄今为止，临床医生几乎没有可改变结果的治疗方法。本综述将重点介绍急性肾功能衰竭的诊断、病理生理学、预防和治疗等方面的临床和基础科学研究进展。急性肾功能衰竭的敏感，预测性生物标志物的发展可能有助于早期诊断综合征，并允许有意义的治疗干预。许多新的治疗急性肾衰竭的方法正在开发中。许多急性肾功能衰竭的动物模型显示出希望，但在人类的前瞻性研究是lacked.SummaryDespite目前缺乏治疗和预防急性肾功能衰竭的疗法，有理由乐观。最近的研究导致了几种不同策略的发展，这些策略可能为急性肾衰竭的治疗提供突破。
Purpose of reviewAcute renal failure causes considerable morbidity and mortality in critically ill patients. To date, there are few therapies available to clinicians that alter outcome. This review will focus on clinical and basic science research efforts related to the diagnosis, pathophysiology, prevention, and treatment of acute renal failure.Recent findingsThe incidence of acute renal failure may be increasing and the mortality rate continues to be significant. The development of sensitive, predictive biomarkers of acute renal failure may help to diagnose the syndrome earlier and allow for meaningful therapeutic intervention. A number of new therapies are in development for acute renal failure. Many show promise in animal models of acute renal failure but prospective studies in humans are lacking.SummaryDespite the present lack of therapies for the treatment and prevention of acute renal failure, there are reasons to be optimistic. Recent research has led to the development of several different strategies that may provide a breakthrough in the treatment of acute renal failure.