Bat-1 genes and the origin of multiple class I loci in the H-2D region.
Bat-1 genes and the origin of multiple class I loci in the H-2D region.
复制标题
Bat-1 基因和 H-2D 区域多个 I 类基因座的起源。
DOI：
10.1007/bf00188791
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发表时间：
1994
期刊：
影响因子：
3.2
通讯作者：
Nakamura,I
中科院分区：
文献类型：
--
作者：
Wroblewski,JM;Kaminsky,SG;Nakamura,I
为了确定H-2d单倍型中人Bat-1 MHC基因的小鼠同源物，对BALB/c衍生的粘粒克隆进行限制性片段长度多态性(RFLP)分析。鉴定出与H-2d单倍型中的D和L位点相关的Bat-1基因的两个拷贝。这些分别被命名为Bat-1a和Bat-1。Bat-1RFLP也在几种标准单倍型的近交小鼠中进行了研究。Bat-1存在于所有研究的单倍型中，但Bat-1b仅在单倍型d、q和v中发现。显示Bat-1a和D位点之间的间隔长度不同。
To define the mouse homologue of the human Bat-1 MHC gene in theH-2dhaplotype, restriction fragment length polymorphism (RFLP) analysis of BALB/c-derived cosmid clones was carried out. Two copies of theBat-1gene, associated with theDandLloci in theH-2dhaplotype, were identified. These were designatedBat-1aandBat-1brespectively.Bat-1RFLPs were also studied in inbred mice of several standard haplotypes.Bat-1awas present in all haplotypes studied, butBat-1bwas found only in haplotypesd,qandv. The interval between theBat-1aandDloci was shown to vary in length.