HOXC10 promotes migration and invasion via the WNT-EMT signaling pathway in oral squamous cell carcinoma
HOXC10 promotes migration and invasion via the WNT-EMT signaling pathway in oral squamous cell carcinoma
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HOXC10通过WNT-EMT信号通路促进口腔鳞状细胞癌的迁移和侵袭
DOI：
10.7150/jca.30645
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发表时间：
2019-01-01
影响因子：
3.9
通讯作者：
Ren, Zhen-Hu
中科院分区：
文献类型：
--
作者：
Dai, Bo-Wen;Yang, Zhi-Min;Ren, Zhen-Hu
含同源结构域基因10 （HOXC10）作为胚胎形态发生的主要调控因子，已被发现可促进人类癌症的进展，并提示不良的生存结果。因此，我们专注于阐明HOXC10在口腔鳞状细胞癌（OSCC）进展中的作用。在我们的研究中，HOXC10在人OSCC样本中的表达显著升高，并与TNM分期和淋巴结转移显著相关。根据Kaplan-Meier生存曲线，HOXC10的上调表明OSCC患者的总生存期较差。此外，敲低hoxc10可显著抑制N-Cadherin、Vimentin和Snail的迁移、侵袭和表达，提高E-cadherin在体内和体外的水平。生物信息学和细胞研究进一步证实，HOXC10可能通过调控WNT/上皮-间充质转化（epithelial-mesenchymal transition， EMT）信号通路促进OSCC细胞的侵袭和迁移。这些发现表明HOXC10在OSCC的转移中起着关键作用，并突出了其作为人类OSCC潜在预后标志物或治疗靶点的有效性。
As a master regulator of embryonic morphogenesis, homeodomain-containing gene 10 (HOXC10) has been found to promote progression of human cancers and indicate poor survival outcome. Therefore, we concentrate on elucidating the role of HOXC10 in progression of oral squamous cell carcinoma (OSCC). In our study, the expression of HOXC10 was significantly increased in human OSCC samples and was significantly correlated with TNM stage and lymph node metastasis. Upregulation of HOXC10 indicated a poor overall survival of OSCC patients according to the Kaplan-Meier survival curves. Furthermore, HOXC10-knockdown dramatically suppressed migration, invasion, and expression of N-Cadherin, Vimentin and Snail, as well as increased E-cadherin level both in vivo and in vitro. Bioinformatics and cellular study further confirmed that HOXC10 may promote invasion and migration of OSCC cells by regulating the WNT/epithelial-mesenchymal transition (EMT) signaling pathway. These findings suggest that HOXC10 plays a pivotal role in the metastasis of OSCC and highlight its usefulness as a potential prognostic marker or therapeutic target in human OSCC.