THE LIN-14 LOCUS OF CAENORHABDITIS-ELEGANS CONTROLS THE TIME OF EXPRESSION OF SPECIFIC POSTEMBRYONIC DEVELOPMENTAL EVENTS
THE LIN-14 LOCUS OF CAENORHABDITIS-ELEGANS CONTROLS THE TIME OF EXPRESSION OF SPECIFIC POSTEMBRYONIC DEVELOPMENTAL EVENTS
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DOI：
10.1101/gad.1.4.398
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发表时间：
1987-06-01
影响因子：
10.5
通讯作者：
HORVITZ, HR
中科院分区：
文献类型：
--
作者：
AMBROS, V;HORVITZ, HR
lin-14基因座的秀丽隐杆线虫在指定的正常时间和顺序的发育事件中起着重要的作用，在侧皮下细胞谱系。基因剂量，互补，和温度变化实验表明，在这些细胞谱系的连续阶段，细胞表达的命运由lin-14活性水平决定，lin-14在这些细胞谱系的连续阶段的作用由lin-14活性水平决定，lin-14在发育过程中多次作用以控制阶段，细胞命运的特定选择。我们的观察表明，在正常发育过程中，14号线基因功能水平的降低导致阶段特异性细胞命运的顺序表达。
The lin-14 locus of Caenorhabditis elegans plays an important role in specifying the normal timing and sequence of developmental events in the lateral hypodermal cell lineages. The results of gene dosage, complementation, and temperature-shift experiments indicate that the fates expressed by cells at successive stages of these cell lineages are specified by the level of lin-14 activity and that lin-14 acts at successive stages of these cell lineages are specified by the level of lin-14 activity and that lin-14 acts as multiple times during development to control stage-specific choices of cell fate. Our observations suggest that during normal development a reduction in the level of line-14 gene function causes the sequential expression of stage-specific cell fates.