The incidence of diagnosed autism spectrum disorders in Finland
The incidence of diagnosed autism spectrum disorders in Finland
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DOI：
10.3109/08039488.2013.861017
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发表时间：
2014-10-01
影响因子：
1.8
通讯作者：
Sourander, Andre
中科院分区：
文献类型：
--
作者：
Hinkka-Yli-Salomaki, Susanna;Banerjee, P. Nina;Sourander, Andre
背景：以前的报告表明自闭症谱系障碍（ASD）的发病率有所增加。目的：首先，基于全国住院和门诊登记信息，评估1996年至1998年出生的儿童中诊断为ASD的发生率。其次，调查1987年至1998年出生的儿童中诊断为ASD的发病率，特别是儿童自闭症，阿斯伯格综合征和广泛性发育障碍（PDD-NOS）。方法：这是一项以人群为基础的队列研究，研究对象为1987年1月1日至2005年12月31日在芬兰出生的儿童；共有120多万儿童。在芬兰医院出院登记簿中确定了儿童，报告的诊断基于国际疾病统计分类（ICD-10, ICD-9）。结果：基于住院和门诊登记数据的ASD年发病率为53.7 / 10,000 （95% CI 50.4-57.2）。男孩发病率为82.6 / 10,000，女孩发病率为23.6 / 10,000，男女性别比（男孩：女孩）为3.5:1。根据住院登记信息，我们报告了1987年至1992年间出生的被诊断为ASD的儿童，特别是儿童自闭症、阿斯伯格综合征和PDD-NOS的发病率增加了8倍。结论：对ASD认识的提高、更精确的诊断标准和自闭症诊断实践的改变可能对1987年至1992年住院治疗ASD病例发生率的增加产生了实质性影响。1992年至1998年间，基于住院和门诊服务使用的发病率保持相当稳定。
Background: Previous reports indicate an increase in incidence of autism spectrum disorders (ASD). Aims: First, to assess the incidence of diagnosed ASD in children born between 1996 and 1998, based on nationwide inpatient and outpatient register information. Second, to investigate the incidence rate over time of diagnosed ASD and specifically childhood autism, Asperger's syndrome and pervasive developmental disorder (PDD-NOS) in children born between 1987 and 1998. Methods: This is population-based cohort study with children born in Finland between 1 January 1987 and 31 December 2005; a total of more than 1.2 million children. Children were identified in the Finnish Hospital Discharge Register, and the reported diagnoses were based on the International Statistical Classification of Diseases (ICD-10, ICD-9). Results: The annual incidence rate of diagnosed ASD based on inpatient and outpatient register data was 53.7 per 10,000 (95% CI 50.4-57.2). Incidence was 82.6 per 10,000 in boys and 23.6 per 10,000 in girls, yielding a sex ratio (boys: girls) of 3.5: 1. We report an eightfold increase in the incidence rates in children of diagnosed ASD and specifically in childhood autism, Asperger's syndrome and PDD-NOS and born between 1987 and 1992 based on inpatient register information. Conclusions: Increased awareness of ASD, more precise diagnostic criteria and changes in practice for diagnosing autism may have had a substantial effect on the increased incidence of inpatient treated ASD cases from 1987 to 1992. Between 1992 and 1998, the incidence rate based on inpatient and outpatient service use remained rather stable.