A conflict rat model of cue-induced relapse to cocaine seeking
A conflict rat model of cue-induced relapse to cocaine seeking
复制标题
DOI：
10.1007/s00213-007-0827-7
复制
发表时间：
2007-09-01
影响因子：
3.4
通讯作者：
Zangen, Abraham
中科院分区：
文献类型：
--
作者：
Cooper, Ayelet;Barnea-Ygael, Noam;Zangen, Abraham
暴露于药物相关线索可诱导人类药物使用复发。在实验室动物中使用恢复模型研究了药物线索引起“复发”的能力，在恢复模型中，在药物强化反应消退后评估药物寻求的恢复。在这个模型中，没有药物寻求行为的不良后果。然而，在人类中，禁欲往往是自我强加的，复发事件可能涉及在对药物的渴望和追求它的负面后果（冲突局势）之间做出选择。在本文中，我们描述了一个冲突模型的线索诱导复发的大鼠，接近人类condition.Materials和方法大鼠进行训练，杠杆按可卡因;输注配对的离散光线索。一个“电屏障”，然后引入了通过扩大地板面积附近的杠杆。随着电击强度的增加，反应在几天内下降，直到大鼠在3天内没有接近杠杆。随后，间歇性的noncontingent光提示介绍杠杆响应（复发）恢复的效果进行了评估，在消光测试中，与电屏障保持激活;在测试过程中，杠杆压力导致特遣队光提示presentation.Results Noncontingent线索曝光导致恢复杠杆压力在复发测试中的14 24只大鼠。令人惊讶的是，24小时后，24只大鼠中的11只在随后的非偶然线索测试中恢复了杠杆反应。在这两个tests.Conclusions在其目前的发展阶段，冲突复发模型出现特别适合于研究线索诱导的复发可卡因寻求或因素，促进这种复发的个体差异。
Rationale Relapse to drug use in humans can be induced by exposure to drug-associated cues. The ability of drug cues to provoke 'relapse' has been studied in laboratory animals using a reinstatement model in which resumption of drug seeking is assessed after extinction of drug-reinforced responding. In this model, there are no adverse consequences of drug-seeking behavior. However, in humans, abstinence is often self-imposed, and relapse episodes likely involve making a choice between the desire for the drug and the negative consequences of pursuing it (a conflict situation). In this paper, we describe a conflict model of cue-induced relapse in rats that approximate the human condition.Materials and methods Rats were trained to lever press for cocaine; infusions were paired with a discrete light cue. An 'electric barrier' was then introduced by electrifying the floor area near the levers. Responding decreased over days with increasing shock intensities, until the rats did not approach the levers for 3 days. Subsequently, the effect of intermittent noncontingent light-cue presentations on resumption of lever responding (relapse) was assessed in extinction tests, with the electric barrier remaining activated; during testing, lever presses led to contingent light-cue presentations.Results Noncontingent cue exposure led to resumption of lever presses during the relapse tests in 14 of the 24 rats. Surprisingly, 24 h later, 11 of the 24 rats resumed lever responding in a subsequent post-noncontingent cue test under similar extinction conditions. Large individual differences in responding were observed during both tests.Conclusions At its current stage of development, the conflict relapse model appears particularly suitable for studying individual differences in cue-induced relapse to cocaine seeking or factors that promote this relapse.