Expeditious and Practical Synthesis of Various Substituted Taurines from Amino Alcohols.
Expeditious and Practical Synthesis of Various Substituted Taurines from Amino Alcohols.
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DOI：
10.1002/chin.200823060
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发表时间：
2008-06
期刊：
影响因子：
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通讯作者：
Wei Zhang;Boyuan Wang;N. Chen;D. Du;Jiaxi Xu
中科院分区：
文献类型：
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作者：
Wei Zhang;Boyuan Wang;N. Chen;D. Du;Jiaxi Xu
以氨基醇为原料，经硫酸酯化和亚硫酸钠取代两步一锅法直接合成了各种取代牛磺酸，产率较高。用同样的方法处理氨基取代的仲醇得到2-取代或1，2-二取代牛磺酸，这表明在取代步骤中形成了氮杂环丙烷作为中间体。该方法是制备结构多样的2-取代和1，2-和2，2-二取代牛磺酸的最有效途径之一。
Various substituted taurines have been synthesized expeditiously and practically in satisfactory to good yields directly from amino alcohols using a two-step, one-pot procedure, in which the amino alcohols undergo sulfuric acid esterification and subsequent sodium sulfite substitution. Treatment of amino-substituted secondary alcohols using the same procedure gave 2-substituted or 1, 2-disubstituted taurines, indicating the formation of aziridines as intermediates during the substitution step. This method is one of the most efficient routes for preparing structurally diverse 2-substituted and 1, 2-and 2, 2-disubstituted taurines.