PRENATAL ALCOHOL EXPOSURE ALTERS THE DEVELOPMENT OF SYMPATHETIC SYNAPTIC COMPONENTS AND OF NERVE GROWTH-FACTOR RECEPTOR EXPRESSION SELECTIVITY IN LYMPHOID ORGANS
PRENATAL ALCOHOL EXPOSURE ALTERS THE DEVELOPMENT OF SYMPATHETIC SYNAPTIC COMPONENTS AND OF NERVE GROWTH-FACTOR RECEPTOR EXPRESSION SELECTIVITY IN LYMPHOID ORGANS
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DOI：
10.1002/jnr.490260307
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发表时间：
1990-07-01
影响因子：
4.2
通讯作者：
PEREZPOLO, JR
中科院分区：
文献类型：
--
作者：
GOTTESFELD, Z;MORGAN, B;PEREZPOLO, JR
子宫内接触酒精与长期免疫缺陷有关。此外，成年小鼠暴露于酒精产前显示改变去甲肾上腺素能突触传递选择性淋巴器官。这与交感神经元在免疫调节中起重要作用的假设是一致的。交感神经元的发育和维持严重依赖于神经生长因子（NGF）。此外，已显示NGF调节免疫应答，并且NGF受体表达已定位于淋巴器官。本工作检查了产前酒精暴露对突触前和突触后交感神经成分（包括去甲肾上腺素和β-肾上腺素）的发育和成熟的影响。肾上腺素能受体，以及早期表达的神经生长因子受体在淋巴和其他器官的C57 BL/6小鼠。在子宫内暴露于酒精的婴儿小鼠显示出降低的去甲肾上腺素和β-肾上腺素水平。肾上腺素受体密度，以及增加的NGF受体表达在胸腺和脾脏，但不是心脏。这些选择性变化可能部分解释了胎儿酒精综合征持续性免疫功能不全的特征。
Exposure to alcohol in utero has been associated with long-term immune deficits. In addition, adult mice exposed to alcohol prenatally display altered noradrenergic synaptic transmission selectively in lymphoid organs. This is consistent with the hypothesis that sympathetic neurons play an important role in immunomodulation. The development and maintenance of sympathetic neurons are critically dependent on nerve growth factor (NGF). Furthermore, NGF has been shown to modulate immune responses and NGF receptor expression has been localized to lymphoid organs. The present work examined the effects of prenatal alcohol exposure on the development and maturation of pre- and postsynaptic sympathetic components, including norepinephrine and .beta.-adrenoceptors, respectively, as well as the early expression of NGF receptors in lymphoid and other organs of the C57BL/6 mouse. Infant mice that were exposed to alcohol in utero displayed reduced levels of norepinephrine and .beta.-adrenoceptor density, as well as increased NGF receptor expression in the thymus and spleen, but not the heart. These selective changes may account, in part, for the persistent immune incompetence characteristic of fetal alcohol syndrome.