Vitreous levels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone
Vitreous levels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone
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DOI：
10.1001/archopht.122.12.1801
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发表时间：
2004-12-01
影响因子：
--
通讯作者：
Grant, MB
中科院分区：
文献类型：
--
作者：
Brooks, HL;Caballero, S;Grant, MB
背景：弥漫性黄斑水肿(DME)和/或异常新生血管(NV)可导致糖尿病视网膜病变(DR)的视力丧失，可能受生长因子和趋化因子的调节。趋化因子基质衍生因子1(SDF-1)是血管内皮生长因子(VEGF)表达的有力刺激因子，是NV的主要效应因子，也是DME相关血管通透性的关键诱导物。目的：探讨不同程度DR和DME患者眼内注射曲安奈德治疗难治性DME前后玻璃体中SDF-1与血管内皮生长因子(VEGF)的关系。用酶联免疫吸附试验检测玻璃体液中血管内皮生长因子和SDF-1的水平。结果：血管内皮生长因子和SDF-1在注射前和注射后1个月均显著升高(P
Background: Diffuse macular edema (DME) and/or aberrant neovascularization (NV) can cause vision loss in diabetic retinopathy (DR) and may be modulated by growth factors and chemokines. The chemokine stromal-derived factor 1 (SDF-1) is a potent stimulator of vascular endothelial growth factor (VEGF) expression, the main effector of NV, and the key inducer of vascular permeability associated with DME. Circulating endothelial cell precursors migrating in response to SDF-1 participate in NV.Objective: To investigate the relationship between SDF-1 and (VEGF) in vitreous of patients with varying degrees of DR and DME before and after intraocular injection of triamcinolone acetonide, used to treat refractory DME.Methods: In this prospective study, 36 patients were included and observed for 6 months. Vitreous VEGF and SDF-1 levels were measured by enzyme-linked immunosorbent assay in samples obtained. immediately before and 1 month after injection of triamcinolone.Results: Both VEGF and SDF-1 were significantly higher (P