Stimulus-Response Profile during Single-Pulse Transcranial Magnetic Stimulation to the Primary Motor Cortex
Stimulus-Response Profile during Single-Pulse Transcranial Magnetic Stimulation to the Primary Motor Cortex
复制标题
DOI：
10.1093/cercor/bhp013
复制
发表时间：
2009-11-01
期刊：
影响因子：
3.7
通讯作者：
Fukuyama, Hidenao
中科院分区：
文献类型：
--
作者：
Hanakawa, Takashi;Mima, Tatsuya;Fukuyama, Hidenao
在单脉冲经颅磁刺激（TMS）期间，我们通过肌电监测测量运动诱发电位（MEPs）和功能磁共振成像（fMRI）在3特斯拉时的血流动力学反应来检查刺激-反应谱。在16名健康受试者中，以平均频率为0.15 Hz的单次TMS脉冲不规则地传递到左初级运动皮层，刺激强度范围广泛。在TMS-fMRI并发环境下，MEP的测量证实了刺激强度与MEP幅值之间的典型关系。在阈上刺激条件的总体水平分析中，在运动/体感网络中检测到血流动力学反应的显著增加，反映了经颅磁刺激的直接和远程效应，也反映了听觉/认知区域，可能与检测咔哒声有关。直接和远程运动/体感网络的刺激-反应谱显示线性和非线性成分。详细分析表明，除了运动引起的感觉传入外，运动/体感网络活动的非线性成分可能还由神经元的非线性募集引起。这些发现扩展了我们对经颅磁刺激诱导的神经激活与神经成像技术测量的血流动力学信号之间定量关系的基本认识。
We examined the stimulus-response profile during single-pulse transcranial magnetic stimulation (TMS) by measuring motor-evoked potentials (MEPs) with electromyographic monitoring and hemodynamic responses with functional magnetic resonance imaging (fMRI) at 3 Tesla. In 16 healthy subjects, single TMS pulses were irregularly delivered to the left primary motor cortex at a mean frequency of 0.15 Hz with a wide range of stimulus intensities. The measurement of MEP proved a typical relationship between stimulus intensity and MEP amplitude in the concurrent TMS-fMRI environment. In the population-level analysis of the suprathreshold stimulation conditions, significant increases in hemodynamic responses were detected in the motor/somatosensory network, reflecting both direct and remote effects of TMS, and also the auditory/cognitive areas, perhaps related to detection of clicks. The stimulus-response profile showed both linear and nonlinear components in the direct and remote motor/somatosensory network. A detailed analysis suggested that the nonlinear components of the motor/somatosensory network activity might be induced by nonlinear recruitment of neurons in addition to sensory afferents resulting from movement. These findings expand our basic knowledge of the quantitative relationship between TMS-induced neural activations and hemodynamic signals measured by neuroimaging techniques.