Effectiveness and kinetic behaviour of tilmicosin in the treatment of respiratory infections in sheep
Effectiveness and kinetic behaviour of tilmicosin in the treatment of respiratory infections in sheep
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DOI：
10.1136/vr.148.25.773
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发表时间：
2001-06-23
影响因子：
2.2
通讯作者：
Carli, S
中科院分区：
文献类型：
--
作者：
Naccari, F;Giofrè, F;Carli, S
19只绵羊出现腹泻、发热、咳嗽、呼吸困难，听诊时有鼻涕和症状性胸廓音，接受10 mg/kg体重的替米考星单次皮下给药。临床症状在4 - 6天内消除。在5只健康绵羊和5只感染绵羊中比较了单次皮下注射后药物的动力学特征。受感染的动物吸收了更多的药物，其浓度在更长的时间内保持在较高水平。该药物耐受性良好，未观察到局部或全身副作用。
Nineteen sheep which were anorexic, pyrexic, coughing dyspnoeic and had a nasal discharge and symptomatic thoracic sounds on auscultation, received a single subcutaneous dose of 10 mg/kg bodyweight of tilmicosin. The clinical signs were eliminated within four to six days. The kinetic profiles of the drug after a single subcutaneous injection were compared in five healthy sheep and five infected sheep. More of the drug was absorbed by the infected animals and its concentration remained higher for significantly longer. The drug was well tolerated and no local or systemic side effects were observed.