Establishment and Dysfunction of the Blood-Brain Barrier.
Establishment and Dysfunction of the Blood-Brain Barrier.
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DOI：
10.1016/j.cell.2015.10.067
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发表时间：
2015-11-19
期刊：
影响因子：
64.5
通讯作者：
Zlokovic BV
中科院分区：
文献类型：
--
作者：
Zhao Z;Nelson AR;Betsholtz C;Zlokovic BV
结构和功能性大脑连接、突触活动和信息处理需要神经血管单元内不同细胞类型之间高度协调的信号转导和完整的血脑屏障（BBB）功能。在这里，我们研究了调节 BBB 形成和维持的机制以及 BBB 相关细胞类型的功能。此外，我们讨论了越来越多的证据表明血脑屏障破坏与遗传性单基因神经系统疾病和复杂的多因素疾病（包括阿尔茨海默病）的发病机制相关。
Structural and functional brain connectivity, synaptic activity and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurological disorders and complex multifactorial diseases including Alzheimer’s disease.