A CASE-CONTROL STUDY OF MULTIPLE-SCLEROSIS
A CASE-CONTROL STUDY OF MULTIPLE-SCLEROSIS
复制标题
DOI：
10.1212/wnl.39.6.825
复制
发表时间：
1989-06-01
期刊：
影响因子：
9.9
通讯作者：
DETELS, R
中科院分区：
文献类型：
--
作者：
OPERSKALSKI, EA;VISSCHER, BR;DETELS, R
We conducted a study of 145 persons with multiple sclerosis who had been identified in a 1970 survey and 145 friend controls, to investigate whether the development of MS was associated with exposure to uncommon viruses or an older age at infection with 1 or more common viruses. The most striking finding was a strong positive association for history of infectious mononucleosis (IM), suggesting older age at exposure to Epstein-Barr virus, the most common etiologic agent of IM. We also found significant positive associations for number of different domiciles before adulthood and for visits outside the United States; both would be compatible with an increased likelihood among cases of exposures to uncommon viruses or to multiple strains of a common agent. Cases were younger at menarche, increasing the probability of viral exposure after puberty.
