Renal tubular antigens in kidney tumors
Renal tubular antigens in kidney tumors
复制标题
肾肿瘤中的肾小管抗原
作者：
BA A. C. WALLACE;MD R. C. Nairn
采用分别与近端肾小管刷状缘区（BB）和远端肾小管Tamm-Horsfall蛋白（TH）反应的两种抗血清，对31例不同类型的人肾肿瘤中的这些抗原进行免疫荧光研究。所有15个皮质腺瘤和11个癌中的10个含有BB抗原，但不含TH抗原。一个未分化癌研究缺乏BB抗原，并与一个颗粒细胞癌表现出弱TH抗原性。检查的两个肾母细胞瘤含有两种抗原。这些发现提供了更多的证据，腺瘤和癌起源于近端肾小管上皮，而肾母细胞瘤起源于更原始的后肾细胞。
Two antisera reacting respectively with the brush border region of proximal renal tubules (BB) and Tamm‐Horsfall protein in distal tubules (TH) were employed for immunofluorescence studies of these antigens in 31 human kidney tumors of different types. All 15 cortical adenomas and 10 of 11 carcinomas contained the BB antigen but not the TH antigen. One anaplastic carcinoma studied lacked the BB antigen and together with one granular cell carcinoma showed weak TH antigenicity. The two Wilms' tumors examined contained both antigens. The findings provide additional evidence that the adenomas and carcinomas arise from proximal tubular epithelium and Wilms' tumors from more primitive metanephric cells.