Pursuit eye movements as an intermediate phenotype across psychotic disorders: Evidence from the B-SNIP study.
Pursuit eye movements as an intermediate phenotype across psychotic disorders: Evidence from the B-SNIP study.
复制标题
DOI：
10.1016/j.schres.2015.09.032
复制
发表时间：
2015-12
影响因子：
4.5
通讯作者：
Sweeney JA
中科院分区：
文献类型：
--
作者：
Lencer R;Sprenger A;Reilly JL;McDowell JE;Rubin LH;Badner JA;Keshavan MS;Pearlson GD;Tamminga CA;Gershon ES;Clementz BA;Sweeney JA
平滑追踪眼动追踪缺陷是精神分裂症的一个有希望的中间表型，可能更广泛地用于精神病性障碍。中间型双极-精神分裂症网络（B-SNIP）协会调查了精神障碍中不同追求参数的严重程度和熟悉程度。先证者精神分裂症（N=265），情感障碍（N=178），精神病性双相情感障碍（N=231），他们的一级亲属（N=306，N=217，N=273，分别）和健康对照组（N=305）进行追求跟踪任务，旨在评估感觉运动和认知/预测方面的追求。与对照组相比，来自所有诊断组的先证者在所有关注的追踪测量上受损（p<0.001）。精神分裂症先证者比其他先证者组在早期追求增益和预测增益方面受损更严重。亲属和没有增强精神病谱人格特质受损的初始眼加速度，最直接的感觉运动的追求措施，但不追求增益措施。这表明，早期感觉运动功能的改变可能会跟踪精神病的易感性，即使在没有精神病相关的人格特征。三组先证者亲属之间的追求措施没有差异。家族性估计的追求赤字表明，早期的追求增益比预测增益，这一直是最广泛使用的措施，在以前的家庭研究的精神病性障碍的家族性。因此，虽然疾病相关的因素可能会引起显着的损害的追求增益，特别是在精神分裂症，赤字的模式在亲属和他们的家庭估计表明，在追求发作的感觉运动功能的改变可能表明增加跨精神障碍的易感性。
Smooth pursuit eye tracking deficits are a promising intermediate phenotype for schizophrenia and possibly for psychotic disorders more broadly. The Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium investigated the severity and familiality of different pursuit parameters across psychotic disorders. Probands with schizophrenia (N=265), schizoaffective disorder (N=178), psychotic bipolar disorder (N=231), their first-degree relatives (N=306, N=217, N=273, respectively) and healthy controls (N=305) performed pursuit tracking tasks designed to evaluate sensorimotor and cognitive/predictive aspects of pursuit. Probands from all diagnostic groups were impaired on all pursuit measures of interest compared to controls (p<0.001). Schizophrenia probands were more impaired than other proband groups on both early pursuit gain and predictive gain. Relatives with and without enhanced psychosis spectrum personality traits were impaired on initial eye acceleration, the most direct sensorimotor pursuit measure, but not on pursuit gain measures. This suggests that alterations in early sensorimotor function may track susceptibility to psychosis even in the absence of psychosis related personality traits. There were no differences in pursuit measures between relatives of the three proband groups. Familiality estimates of pursuit deficits indicate that early pursuit gain was more familial than predictive gain, which has been the most widely used measure in previous family studies of psychotic disorders. Thus, while disease-related factors may induce significant impairments of pursuit gain, especially in schizophrenia, the pattern of deficits in relatives and their familiality estimates suggest that alterations in sensorimotor function at pursuit onset may indicate increased susceptibility across psychotic disorders.