Chromium-mediated hyperpigmentation of skin in male tannery workers in Bangladesh
Chromium-mediated hyperpigmentation of skin in male tannery workers in Bangladesh
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DOI：
10.1016/j.chemosphere.2019.04.112
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发表时间：
2019-08-01
期刊：
影响因子：
8.8
通讯作者：
Kato, Masashi
中科院分区：
文献类型：
--
作者：
Al Hossain, M. M. Aeorangajeb;Yajima, Ichiro;Kato, Masashi
由于发展中国家的制革工人长期暴露于高水平的铬（Cr），因此存在严重的健康问题。然而，有有限的研究中，铬水平测定制革工人，谁是长期暴露于铬。我们的初步检查表明制革工人的皮肤色素沉着。因此，我们调查了皮肤色素沉着水平的数字化评估L* 值之间的相关性，通过使用反射分光光度计和铬水平的皮肤附件中的100名男性制革工人和49名男性非制革工人在孟加拉国。数字化的皮肤色素沉着水平的脸和脚除了铬水平在制革工人的头发和脚趾甲显着高于非制革工人在我们的单变量分析。斯皮尔曼等级相关系数分析表明，制革年限与发铬（r = 0.62）和甲铬（r = 0.61）呈显著正相关。我们的多变量分析还表明，在所有参与者中，头发和脚趾甲中的铬水平与面部和足部的数字化皮肤色素沉着水平以及制革工作的持续时间显著相关。因此，我们的研究结果显示了制革工人色素沉着皮肤的发展。我们的研究结果还表明，色素沉着的皮肤可能是一个有用的诊断标记慢性暴露于铬。此外，皮肤L* 值可能是检测慢性铬中毒的一个方便的标志物，因为数字化的值使普通人以及皮肤科医生能够客观评价皮肤色素水平。(C)2019由Elsevier Ltd.出版
Since tannery workers in developing countries are chronically exposed to high levels of chromium (Cr), there are serious concerns about health problems. However, there has been limited study in which Cr levels were measured in tannery workers, who are chronically exposed to Cr. Our preliminary inspection showed that there was hyperpigmented skin in tannery workers. We therefore investigated the correlation between skin pigmentation levels digitally evaluated as L* values by using a reflectance spectrophotometer and Cr levels in skin appendages in 100 male tannery workers and in 49 male non-tannery workers in Bangladesh. Digitalized skin pigmentation levels of the face and feet in addition to Cr levels in hair and toenails in tannery workers were significantly higher than those in non-tannery workers in our univariate analysis. Spearman's rank correlation coefficient analysis showed significant correlation between duration of tannery work (years) and Cr levels in hair (r = 0.62) and toenails (r = 0.61). Our multivariate analysis also showed that Cr levels in hair and toenails were significantly correlated with digitalized skin pigmentation levels of the face and feet in addition to duration of tannery work in all participants. Thus, our results showed the development of hyperpigmented skin in tannery workers. Our results also suggested that hyperpigmented skin could be a useful diagnostic marker for chronic exposure to Cr. Furthermore, cutaneous L* value might be a convenient marker for detection of chronic Cr poisoning, since the digitalized values enable objective evaluation of skin pigmented levels by general people as well as dermatologists. (C) 2019 Published by Elsevier Ltd.