A Stem Cell Approach to Cure Type 1 Diabetes.
A Stem Cell Approach to Cure Type 1 Diabetes.
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DOI：
10.1101/cshperspect.a035741
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发表时间：
2021-01-04
影响因子：
7.2
通讯作者：
Melton, Douglas A
中科院分区：
文献类型：
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作者：
Helman, Aharon;Melton, Douglas A
胰岛素注射治疗1型糖尿病是昂贵的，复杂的，和不足。虽然尸体胰岛移植加上免疫抑制剂可以治愈糖尿病，但可接受的胰岛的稀缺性是个问题。关于胰腺形成的发育研究已经为人类多能干细胞体外分化为功能性胰岛提供了信息。虽然从干细胞中产生β细胞为1型糖尿病提供了潜在的治疗方法，但仍然存在一些挑战，包括保护细胞免受免疫系统的影响。
Treatment of type 1 diabetes with insulin injection is expensive, complicated, and insufficient. While cadaveric islet transplantations coupled with immunosuppressants can cure diabetes, the scarcity of acceptable islets is problematic. Developmental research on pancreas formation has informed in vitro differentiation of human pluripotent stem cells into functional islets. Although generating beta cells from stem cells offers a potential cure for type 1 diabetes, several challenges remain, including protecting the cells from the immune system.