Pulmonary hypertension is an independent predictor of cardiovascular events and mortality in haemodialysis patients
Pulmonary hypertension is an independent predictor of cardiovascular events and mortality in haemodialysis patients
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DOI：
10.1111/nep.12595
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发表时间：
2016-04-01
期刊：
影响因子：
2.5
通讯作者：
Manuel Lopez-Gomez, J.
中科院分区：
文献类型：
--
作者：
Reque, Javier;Quiroga, Borja;Manuel Lopez-Gomez, J.
目的探讨肺动脉高压（PH）的发病率、相关因素及其对患者预后的影响，方法对211例血液透析患者，采用二维多普勒超声心动图（2D-Doppler echocardiography，2D-Doppler echocardiography，2D-Doppler echocardiography）测定肺动脉收缩压（SPAP），将PH定义为SPAP> 35 mmHg，中位随访时间为39个月（19-56个月）。主要终点为全因死亡率和心血管事件。年龄、既往心血管疾病史、Nt-pro-BNP水平、hs-TnT、收缩功能障碍、舒张功能障碍和左室肥厚是PH的独立影响因素。随访期间共发生94例心血管事件，相关变量为：PH、年龄、心血管疾病史、血脂异常、Nt-pro-BNP和hs-TnT浓度升高、收缩和舒张功能障碍，在多变量模型中，PH保持独立相关性。死亡率：88例（41.7%），其中无PH组35例（29.5%），PH组53例（58.5%）（P
AimThe evidence about prevalence, associated factors of pulmonary hypertension (PH) and its impact on patient's outcomes is limited.MethodsWe included 211 haemodialysis patients, we estimated the systolic pulmonary artery pressure (SPAP) by 2D Doppler echocardiography defining PH as a SPAP above 35mmHg, the median follow-up was 39 (19-56) moths, and the primary endpoints were all cause mortality and cardiovascular events.ResultsWe found PH in 91 patients (43.9%). Independent determinants of PH were age, previous cardiovascular disease, the Nt-pro-BNP level hs-TnT, the systolic dysfunction, diastolic dysfunction and left ventricular hypertrophy. Over the follow-up 94 cardiovascular events occurred, variables associated were: PH, age, history cardiovascular disease, dyslipidaemia, elevated concentration of Nt-pro-BNP and hs-TnT, systolic and diastolic dysfunction, in a multivariate model, the PH maintained its independent association. Mortality data: 88 patients died (41.7%); 35 (29.5%) in the no PH group and 53 (58.5%) in the PH group (P