Olefin-Assisted Iron-Catalyzed Alkylation of Aryl Chlorides
Olefin-Assisted Iron-Catalyzed Alkylation of Aryl Chlorides
复制标题
DOI：
10.1002/adsc.201300095
复制
发表时间：
2013-08-12
影响因子：
5.4
通讯作者：
Jacobi von Wangelin, Axel
中科院分区：
文献类型：
--
作者：
Guelak, Samet;Gieshoff, Tim N.;Jacobi von Wangelin, Axel
发展了一种选择性和操作简单的铁催化芳基氯与烷基镁卤化物的交叉偶联反应。该反应容忍各种官能团，并表现出高的化学选择性，甚至在芳基溴的存在下。机理研究表明，底物活化的烯烃取代基的重要作用。有效地抑制了竞争聚合和还原。
A selective and operationally simple iron-catalyzed cross-coupling of aryl chlorides with alkylmagnesium halides has been developed. The reaction tolerates various functional groups and exhibits high chemoselectivity even in the presence of aryl bromides. Mechanistic studies indicate the essential role of the olefin substituent for substrate activation. Competing polymerization and reduction are effectively suppressed.