INTERFERON ACTION - RNA CLEAVAGE PATTERN OF A (2'-5')OLIGOADENYLATE-DEPENDENT ENDONUCLEASE
INTERFERON ACTION - RNA CLEAVAGE PATTERN OF A (2'-5')OLIGOADENYLATE-DEPENDENT ENDONUCLEASE
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DOI：
10.1126/science.6165080
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
LENGYEL, P
中科院分区：
文献类型：
--
作者：
FLOYDSMITH, G;SLATTERY, E;LENGYEL, P
干扰素作用的介质之一是由（2“-5”）寡腺苷酸激活的潜伏性内切RNA酶（RNA酶L）。在4种常见核糖核苷酸的均聚物中，活化的RNase L [来自小鼠埃利希腹水肿瘤细胞]仅以可观的速率降解聚（U）。在2种天然RNA中，最常见的RNase L切割发生在UA、UG和UU之后，而在CA和AC之后的切割频率要低得多。
One of the mediators of interferon action is a latent endoRNase (RNase L) that is activated by (2''-5'')oligoadenylates. Among the homopolymers of the 4 common ribonucleotides, activated RNase L [from mouse Ehrlich ascites tumor cells] degrades at an appreciable rate only poly(U). In 2 natural RNA tested the most frequent RNase L cleavages occur after UA, UG and UU and much less frequent cleavages after CA and AC.