Contrasting brain activity patterns for item recognition memory and associative recognition memory: Insights from immediate-early gene functional imaging
Contrasting brain activity patterns for item recognition memory and associative recognition memory: Insights from immediate-early gene functional imaging
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DOI：
10.1016/j.neuropsychologia.2012.05.018
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发表时间：
2012-11-01
期刊：
影响因子：
2.6
通讯作者：
Albasser, Mathieu M.
中科院分区：
文献类型：
--
作者：
Aggleton, John P.;Brown, Malcolm W.;Albasser, Mathieu M.
识别记忆，即区分小说和熟悉事件的能力，可以分为项目识别和联想识别。物品识别涉及识别新颖的个体刺激，而联想识别涉及检测当熟悉的物品以新颖的方式重新配置时出现的新颖性。在啮齿类动物中进行的实验绘制了早期基因（例如 c-fos）的表达图谱，突显了这两种形式的识别记忆之间的关键差异。视觉项目的新颖性始终与两个大脑部位（即鼻周皮层和邻近的视觉关联区域 Te2）中 c-fos 活性的增加有关。通常海马 c-fos 没有变化。相比之下，视觉联想识别始终与海马体中的 c-fos 活性变化相关，但与鼻周皮层无关。缺乏带有联想识别的 c-fos 鼻周变化可能反映了这样一个事实：阵列中的各个项目仍然是熟悉的，即使它们的组合是独特的。当物品识别与海马 c-fos 变化相关时，这些例外情况会在大鼠积极探索新物体时发生。与物体的接触增加将涉及多感官刺激处理，并可能创造条件，使大鼠可以轻松学习刺激属性，例如物体位置或物体顺序，即涉及联想识别的属性。基于颞叶立即早期基因表达水平的相关性表明，积极探索新的刺激会改变内嗅-海马功能连接的模式，以强调直接的内嗅-齿状回处理。这些基因活性发现有助于区分内侧颞叶功能模型。 (C) 2012 Elsevier Ltd. 保留所有权利。
Recognition memory, the discrimination of a novel from a familiar event, can be classified into item recognition and associative recognition. Item recognition concerns the identification of novel individual stimuli, while associative recognition concerns the detection of novelty that arises when familiar items are reconfigured in a novel manner. Experiments in rodents that have mapped the expression of immediate-early genes, e.g., c-fos, highlight key differences between these two forms of recognition memory. Visual item novelty is consistently linked to increased c-fos activity in just two brain sites, the perirhinal cortex and the adjacent visual association area Te2. Typically there are no hippocampal c-fos changes. In contrast, visual associative recognition is consistently linked to c-fos activity changes in the hippocampus, but not the perirhinal cortex. The lack of a c-fos perirhinal change with associative recognition presumably reflects the fact that the individual items in an array remain familiar, even though their combinations are unique. Those exceptions, when item recognition is associated with hippocampal c-fos changes, occur when rats actively explore novel objects. The increased engagement with objects will involve multisensory stimulus processing and potentially create conditions in which rats can readily learn stimulus attributes such as object location or object order, i.e., attributes involved in associative recognition. Correlations based on levels of immediate-early gene expression in the temporal lobe indicate that actively exploring novel stimuli switches patterns of entorhinal-hippocampal functional connectivity to emphasise direct entorhinal-dentate gyrus processing. These gene activity findings help to distinguish models of medial temporal lobe function. (C) 2012 Elsevier Ltd. All rights reserved.