Effect of meditation on endothelial function in Black Americans with metabolic syndrome: a randomized trial.
Effect of meditation on endothelial function in Black Americans with metabolic syndrome: a randomized trial.
复制标题
冥想对患有代谢综合征的美国黑人内皮功能的影响：一项随机试验。
DOI：
10.1097/psy.0b013e31829ac4f4
复制
发表时间：
2013
影响因子：
3.3
通讯作者：
Quyyumi,ArshedA
中科院分区：
文献类型：
--
作者：
Vaccarino,Viola;Kondwani,KofiA;Kelley,MaryE;Murrah,NancyV;Boyd,Linda;Ahmed,Yusuf;Meng,YuanX;Gibbons,GaryH;Hooper,WCraig;DeStaercke,Christine;Quyyumi,ArshedA
目的心理应激可能在代谢综合征中起一定作用。代谢综合征的后果是内皮功能障碍，这也受到心理压力的影响。我们试图比较有意识的休息冥想（CRM），一种基于声音的冥想，与健康教育（HE）的对照干预对代谢综合征患者内皮功能的影响。（年龄，30-65岁）被随机分配到CRM（n= 33）或HE（n= 35）;干预的频率和持续时间相匹配，持续12个月。通过肱动脉血流介导的舒张功能在基线和6个月和12个月时评估内皮功能。动脉弹性，代谢危险因素，心理和行为变量的次要endpoints.ResultsAlthough流量介导的扩张改善CRM组为12个月，这种增加并不显着高于HE组（p=. 001）。51组与时间之间的相互作用）。两组的非内皮依赖性扩张和动脉弹性均无变化。大多数代谢综合征危险因素仅在CRM组中显示出有益的趋势。计算代谢综合征组分数量的危险因素评分仅在CRM组中降低（p=.结论：在具有代谢综合征危险因素的美国黑人中，CRM并没有比HE的对照干预更显著地改善内皮功能。CRM导致代谢综合征危险因素的有利趋势，这被视为次要结局。
ObjectivesPsychological stress may play a role in metabolic syndrome. A consequence of metabolic syndrome is endothelial dysfunction, which is also influenced by psychological stress. We sought to compare the effect of consciously resting meditation (CRM), a sound based meditation, with a control intervention of health education (HE) on endothelial function in the setting of metabolic syndrome.MethodsSixty-eight black Americans with metabolic syndrome risk factors (age, 30–65 years) were randomized to either CRM (n= 33) or HE (n= 35); interventions were matched for frequency and duration of sessions and lasted 12 months. Endothelial function was assessed by brachial artery flow-mediated dilation at baseline and at 6 and 12 months. Arterial elasticity, metabolic risk factors, and psychosocial and behavioral variables were secondary end points.ResultsAlthough flow-mediated dilation improved in the CRM group for 12 months, this increase was not significantly higher than that in the HE group (p=. 51 for the interaction between group and time). Non–endothelium-dependent dilation and arterial elasticity did not change in either group. Most metabolic syndrome risk factors showed beneficial trends in the CRM group only. A risk factor score counting the number of metabolic syndrome components decreased in the CRM group only (p=. 049 for the interaction between treatment group and time).ConclusionsAmong black Americans with metabolic syndrome risk factors, CRM, did not improve endothelial function significantly more than a control intervention of HE. CRM resulted in favorable trends in metabolic syndrome risk factors, which were examined as secondary outcomes.