LONGITUDINAL FIBRE DIVISION IN SKELETAL MUSCLE - A LIGHT-MICROSCOPIC AND ELECTRONMICROSCOPIC STUDY
LONGITUDINAL FIBRE DIVISION IN SKELETAL MUSCLE - A LIGHT-MICROSCOPIC AND ELECTRONMICROSCOPIC STUDY
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DOI：
10.1007/bf00343963
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发表时间：
1970-01-01
期刊：
影响因子：
--
通讯作者：
LAWRENCE, CA
中科院分区：
文献类型：
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作者：
HALLCRAGGS, EC;LAWRENCE, CA
据报道，在超负荷的条件下，肌纤维经历纵向分裂的过程。有人声称，这一过程导致横截面积增加，因此有助于收缩力。然而，最近的研究表明，这种分裂的程度有限，而且显然是病理性的。对挤压损伤附近的材料进行的检查表明，大体创伤也能再现类似的情况。对超负荷和创伤肌肉中的纤维分裂进行的电子显微镜研究证实了它们的相似性，并显示存在萎缩性变化。这一证据足以表明，在超负荷肌肉和可能在营养不良肌肉中看到的纤维纵向分裂是在纤维受损之后发生的，这种方式的分裂可能会使退化部分从纤维中排出。
Under conditions of overloading, muscle fibres have been reported to undergo a process of longitudinal division. It has been claimed that this process leads to an increase in cross-sectional area and therefore contributes to the force of contraction. Recent work, however has demonstrated that the division is of limited extent and apparently pathological in origin. Examination of material taken from the immediate vicinity of a crush lesion has shown that a similar picture is reproduced by gross trauma. An electronmicroscopic study of dividing fibres in both overloaded and traumatized muscles has confirmed their similarity and revealed that atrophic changes are present. This evidence is sufficient to suggest that the longitudinal division of fibres seen in overloaded muscles and possibly in dystrophic muscles follows damage to the fibre and that division in this manner may allow the rejection from it of degenerated portions.