Quantitative assessment of SSTR2 expression in patients with non-small cell lung cancer using 68Ga-DOTATOC PET and comparison with 18F-FDG PET
Quantitative assessment of SSTR2 expression in patients with non-small cell lung cancer using 68Ga-DOTATOC PET and comparison with 18F-FDG PET
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DOI：
10.1007/s00259-005-0063-5
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发表时间：
2006-07-01
影响因子：
9.1
通讯作者：
Strauss, Ludwig G.
中科院分区：
文献类型：
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作者：
Dimitrakopoulou-Strauss, Antonia;Georgoulias, Vassilios;Strauss, Ludwig G.
目的：在非小细胞肺癌（NSCLC）患者中进行Ga-68-DOTATOC动态PET研究，以评估生长抑素受体2（SSTR 2）表达。此外，动态F-18-氟脱氧葡萄糖（FDG）的研究进行了比较SSTR 2的表达与肿瘤violence.Methods：研究人群包括9例患者，检查两种示踪剂在两个不同的日子在1周内。计算标准化摄取值（SUV），并将双组织室模型应用于数据。结果：DOTATOC摄取量普遍低于FDG摄取量。在9个肿瘤中的7个中观察到DOTATOC摄取的中度增强。除k（4）外，DOTATOC的所有动力学参数均低于FDG。DOTATOC的平均SUV为2.018，而FDG为5.683。特别是，DOTATOC的k（3）具有高度可变性，并与正常肺组织重叠。两种示踪剂的分数血液体积V（B）相对较低，不超过0.3。两种示踪剂FD的对数相关性最高（r= 0.764，p =0.017）。SUV与V（B）的对数相关性也非常显著（r= 0.646，p =0.060），V（B）的对数相关性也非常显著（r= 0.629，p =0.069）。相比之下，FDG PET呈阳性的8个转移灶均未显示任何DOTATOC吸收。结论：结果表明原发性非小细胞肺癌中有中度Ga-68-DOTATOC吸收，但没有提供任何转移灶中SSTR 2表达的证据。这可能是由于与原发性肿瘤相比，转移瘤中的基因表达丧失所致。
Purpose: Dynamic PET studies with Ga-68-DOTATOC were performed in patients with non-small cell lung cancer (NSCLC) to assess the somatostatin receptor 2 (SSTR2) expression. Furthermore, dynamic F-18-fluorodeoxyglucose (FDG) studies were performed in the same patients to compare the SSTR2 expression with the tumour viability.Methods: The study population comprised nine patients, examined with both tracers on two different days within 1 week. Standardised uptake values (SUVs) were calculated and a two-tissue compartment model was applied to the data. Furthermore, a non-compartment model based on the fractal dimension (FD) was applied to the data.Results: The DOTATOC uptake was generally lower than the FDG uptake. Moderately enhanced DOTATOC uptake was noted in seven of the nine tumours. All kinetic parameters exceptk (4) were lower for DOTATOC than for FDG. The mean SUV was 2.018 for DOTATOC, in comparison to 5.683 for FDG. In particular,k (3) was highly variable for DOTATOC and showed an overlap with the normal lung tissue. The fractional blood volumeV (B) was relatively low for both tracers, not exceeding 0.3. The highest significant logarithmic correlation was found for the FD of the two tracers (r=0.764,p=0.017). The logarithmic correlation for SUVs was also significant (r=0.646,p=0.060), as was that forV (B) (r=0.629,p=0.069). In contrast, none of the eight metastases which were positive on FDG PET showed any DOTATOC uptake.Conclusion: The results demonstrated moderate Ga-68-DOTATOC uptake in primary NSCLC but did not provide any evidence for SSTR2 expression in metastases. This may be caused by loss of the gene expression in metastases as compared with the primary tumours.