Walking along the Fibroblast Growth Factor 10 Route: A Key Pathway to Understand the Control and Regulation of Epithelial and Mesenchymal Cell-Lineage Formation during Lung Development and Repair after Injury.
Walking along the Fibroblast Growth Factor 10 Route: A Key Pathway to Understand the Control and Regulation of Epithelial and Mesenchymal Cell-Lineage Formation during Lung Development and Repair after Injury.
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DOI：
10.1155/2014/538379
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发表时间：
2014
期刊：
影响因子：
3.2
通讯作者：
Bellusci S
中科院分区：
文献类型：
--
作者：
El Agha E;Bellusci S
胚胎肺发育的基础研究为做出影响人类健康的重要发现提供了独特的机会。对分支形态发生的分子控制感兴趣的发育生物学家已经深入研究了发育中的肺，其复杂且看似刻板的分支结构。然而，它也是一个与人类大量临床问题有关的器官，如早产儿支气管肺发育不良、肺气肿、慢性阻塞性肺病、纤维化和成人癌症。上皮干细胞/祖细胞存在于壁龛中，与特定的细胞外基质以及间充质细胞相互作用；后者的特征仍然很差。上皮干细胞/祖细胞与其微环境的相互作用通常是指导性的，控制着静止与激活、增殖、分化和迁移。在过去的18年中，Fgf10不仅在早期肺发育过程中作为远端肺间质的标记物，而且在分支形态发生和上皮干细胞生态位的关键组成部分中发挥着关键作用。在本文中，我们将介绍目前关于肺谱系树的知识，特别强调肺间质中细胞谱系的决定以及Fgf10在此背景下的作用。
Basic research on embryonic lung development offers unique opportunities to make important discoveries that will impact human health. Developmental biologists interested in the molecular control of branching morphogenesis have intensively studied the developing lung, with its complex and seemingly stereotyped ramified structure. However, it is also an organ that is linked to a vast array of clinical problems in humans such as bronchopulmonary dysplasia in premature babies and emphysema, chronic obstructive pulmonary disease, fibrosis, and cancer in adults. Epithelial stem/progenitor cells reside in niches where they interact with specific extracellular matrices as well as with mesenchymal cells; the latter are still poorly characterized. Interactions of epithelial stem/progenitor cells with their microenvironments are usually instructive, controlling quiescence versus activation, proliferation, differentiation, and migration. During the past 18 years, Fgf10 has emerged not only as a marker for the distal lung mesenchyme during early lung development, but also as a key player in branching morphogenesis and a critical component of the niche for epithelial stem cells. In this paper, we will present the current knowledge regarding the lineage tree in the lung, with special emphasis on cell-lineage decisions in the lung mesenchyme and the role of Fgf10 in this context.