Dynamic permeability and quantitative susceptibility: related imaging biomarkers in cerebral cavernous malformations.
Dynamic permeability and quantitative susceptibility: related imaging biomarkers in cerebral cavernous malformations.
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DOI：
10.1161/strokeaha.113.003548
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发表时间：
2014-02
期刊：
影响因子：
8.3
通讯作者：
Awad I
中科院分区：
文献类型：
--
作者：
Mikati AG;Tan H;Shenkar R;Li L;Zhang L;Guo X;Larsson HB;Shi C;Liu T;Wang Y;Shah A;Edelman RR;Christoforidis G;Awad I
Hyperpermeability and iron deposition are two central pathophysiological phenomena in human cerebral cavernous malformation (CCM) disease. Here we used two novel magnetic resonance imaging (MRI) techniques to establish a relationship between these phenomena. Subjects with CCM disease (4 sporadic and 18 familial) underwent MRI imaging using the Dynamic Contrast Enhanced Quantitative Perfusion (DCEQP) and Quantitative Susceptibility Mapping (QSM) techniques that measure hemodynamic factors of vessel leak and iron deposition respectively, previously demonstrated in CCM disease. Regions of interest encompassing the CCM lesions were analyzed using these techniques Susceptibility measured by QSM was positively correlated with permeability of lesions measured using DCEQP (r=0.49, p=<0.0001). The correlation was not affected by factors including familial predisposition, lesion volume, the contrast agent and the use of statin medication. Susceptibility was correlated with lesional blood volume (r=0.4, p=0.0001), but not with lesional blood flow. The correlation between QSM and DCEQP suggests that the phenomena of permeability and iron deposition are related in CCM; hence “more leaky lesions” also manifest a more cumulative iron burden. These techniques might be used as biomarkers to monitor the course of this disease and the effect of therapy.
