EFFECTS OF EPINEPHRINE ON RESISTIVE AND COMPLIANT PROPERTIES OF CANINE VASCULATURE
EFFECTS OF EPINEPHRINE ON RESISTIVE AND COMPLIANT PROPERTIES OF CANINE VASCULATURE
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DOI：
10.1152/jappl.1975.39.2.272
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发表时间：
1975-01-01
影响因子：
3.3
通讯作者：
GOLDBERG, H
中科院分区：
文献类型：
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作者：
MITZNER, W;GOLDBERG, H
将22只麻醉犬的外周循环分为三个平行区域，测量每个区域的流出量，控制流出和流入压力。因此，我们能够估计每个区域的动脉和静脉阻力和静脉顺应性。在持续输注肾上腺素（3 μ g-kg-1 min-1）之前和过程中测定这些参数的压力依赖性。肾上腺素增加了所有区域的动脉阻力，但其方式是增加了内脏区灌注的心输出量的比例。静脉阻力均因肾上腺素升高，并表现出比对照组更大的压力依赖性。在对照组和肾上腺素给药期间，发现全身静脉依从性都是压力依赖的，从最低静脉压到最高静脉压（4-12 mmHg）下降了近50%。发现内脏顺应性占总系统顺应性的近一半。使用Caldini、Permutt、Waddell和Riley所描述的外周循环平行室模型的扩展来解释结果(2)。
The peripheral circulation of 22 anesthetized dogs was separated into three parallel regions, where the outflow from each region could be measured and both outflow and inflow pressures could be controlled. We were thus able to estimate arterial and venous resistance and venous compliance for each region. The pressure dependency of these parameters was determined before and during continuous infusion of epinephrine (3 mug-kg-1 min-1). Epinephrine increased the arterial resistance in all regions but did so in such manner as to increase the fraction of cardiac output perfusing the splanchnic region. The venous resistances were all elevated by epinephrine and showed a greater pressure dependency than during control. Systemic venous complicance was found to be pressure dependent during both control and epinephrine administration, decreasing by nearly 50% from the lowest to the highest venous pressures (4–12 mmHg) investigated. Splanchnic compliance was found to comprise nearly half the total systemic compliance. Results were interpreted using an extension of the parallel compartment model of the peripheral circulation described by Caldini, Permutt, Waddell, and Riley (2).